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ProteomicsDistinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72)
Frontotemporal dementias are neuropathologically characterized by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathologic hallmark of approximately half of the FTLD cases, being referred to as FTLD-TDP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-12 | MSV000089242 | MassIVE
TranscriptomicsTargeted RNA-seq of FTLD-TDP brain samples
UNC13A features a cryptic exon which is expressed upon loss of nuclear TDP-43. Here, we perform targeted RNA-seq on RNA extracted from 10 FTLD-TDP brain samples, and four control samples, enriching for the cryptic exon via nested PCR. Each FTLD-TDP sample is heterozygous for rs12973192. There are t...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-10237 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human postmortem brain samples with and without FTLD-U
FTLD-U is the most common pathological correlate of the neurodegenerative dementia frontotemporal dementia; We used microarrays to perform global expression profiling of FTLD-U brain samples Experiment Overall Design: Postmortem brain samples were isolated from normal controls, FTLD-U patients with ...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-13162 | biostudies-arrayexpress
Proteomicsproteome analysis of PSP and FTLD subjects
A mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. Here, we applied mass spectrometry-based quantitative proteomics to analyse pathological effects on the olfactory bulb (OB)...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD011446 | Pride
Ftld Proteomics Dementia Psp 
ProteomicsAD and FTLD model mouse, brain, Phosphoproteome
Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in five types of Alzheimer's disease (AD) mouse models (5xFAD, APP-tg, PS1-tg, PS2-tg and APP-KI) and four types of frontotemporal lobar degeneration (FTLD) mouse models(CHMP2B-KI, PGRN-KI, VCP-KI and TDP43-KI) at m...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD027119 | Pride
Ftld Ad Ftd Mouse Phosphoproteome 
ProteomicsTDP-43 in ALS/FTLD studied by a novel aggregate extraction method
Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathological finding characterizing affected neurons in most patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). At least four different subtypes of FTLD-TDP have been described, based ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-10 | PXD007873 | Pride
Ftld Tdp-43 Als 
TranscriptomicsDifferential gene expression study in brain samples from patients suffering distinct frontotemporal lobar degeneration (FTLD) conditions.
RNA extracted from human frontal cortex area 8, the main area afected in FTLD, of controls (n=10), sporadic FTLD-TDP (sFTLD) (n=10) and C9ORF72-familial FTLD (fFTLD) (n=10) samples were analyzed using the Affymetrix Clariom™ D Assay, human (Affymetrix ref.902923). The present study identifies the ma...
ORGANISM(S): Homo sapiens 
2018-09-19 | E-MTAB-6189 | biostudies-arrayexpress
GenomicsNeuronal VCP loss of function recapitulates FTLD-TDP pathology
Neuronal VCP loss of function recapitulates FTLD-TDP pathology
PRJNA738150 | ENA
GenomicsRNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls
RNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls
PRJNA1268606 | ENA
GenomicsRNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls
RNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls
PRJNA1268607 | ENA
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