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TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat [rat]
A need exists for biomarkers in T1D that can 1) sensitively and specifically detect disease-related immune activity prior to, and independent of, measurement of auto-antibodies towards islet cell antigens; 2) define immunopathological mechanisms; and 3) monitor changes in the inflammatory state asso...
ORGANISM(S): Rattus norvegicus 
2013-06-01 | E-GEOD-40497 | biostudies-arrayexpress
TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-06-01 | E-GEOD-40498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and myo1 knock out yeast to examine differential gene expression patterns in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of differential gene expression patterns in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a m...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-559 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pancreatic islets in BioBreeding rats
Like humans, the NOD mouse and other diabetes susceptible rat strains, T1D in BB rats is dependent on the major histocompatibility complex (MHC, insulin dependent diabetes mellitus locus 1, Iddm1) located on chromosome 20. In rats this is the HLA-DQB1 homologue RT1-B, specifically the RT1u haplotype...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20214 | biostudies-arrayexpress
TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat [human]
A need exists for biomarkers in T1D that can 1) sensitively and specifically detect disease-related immune activity prior to, and independent of, measurement of auto-antibodies towards islet cell antigens; 2) define immunopathological mechanisms; and 3) monitor changes in the inflammatory state asso...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-40496 | biostudies-arrayexpress
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