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MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
TranscriptomicsStage-specific regulation of translation revealed by ribosome profiling of Trypanosoma brucei
Trypanosoma brucei subspecies infect humans and animals in sub-Saharan Africa. This early diverging eukaryote shows many novel features in basic biological processes, including the use of polycistronic transcription to generate all protein-coding mRNAs. Therefore we hypothesized that translational...
ORGANISM(S): Trypanosoma brucei 
2014-05-24 | E-GEOD-57336 | biostudies-arrayexpress
TranscriptomicsAdvancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping
Since the initial publication of the trypanosomatid genomes, curation has been ongoing. Here we apply the technique of ribosome profiling to Trypanosoma brucei, identifying 223 new coding regions by virtue of ribosome occupancy in the corresponding transcripts. A small number of these putative genes...
ORGANISM(S): Trypanosoma brucei 
2015-12-22 | E-GEOD-72463 | biostudies-arrayexpress
UnknownA genetic modifier suggests that endurance exercise exacerbates Huntington's disease.
Not available
S-EPMC5932560 | biostudies-literature
UnknownA mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
Not available
S-EPMC5570507 | biostudies-literature
UnknownA Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (<i>NFIX</i>) Gene Has Phenotypic Features of Marshall-Smith Syndrome.
Not available
S-EPMC10241085 | biostudies-literature
UnknownAnalysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.
Not available
S-EPMC9715561 | biostudies-literature
UnknownGenome-wide screening reveals the genetic basis of mammalian embryonic eye development.
Not available
S-EPMC9898963 | biostudies-literature
UnknownDisease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Not available
S-EPMC5546242 | biostudies-literature
UnknownNew models for human disease from the International Mouse Phenotyping Consortium.
Not available
S-EPMC6606664 | biostudies-literature
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