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TranscriptomicsExpression data from C2C12 myoblasts transduced with PRDM16 or vector
PRDM16 is a 140 kDa transcriptional coregulatory protein. PRDM16 has been shown to function as a bi-directional switch in brown fat cell fate by stimulating the development of brown fat cells from myf-5 positive myoblastic precursors. We used microarrays to detail the global programme of gene expres...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15895 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the Retina after Transcorneal Electrical Stimulation in Wildtype Brown Norway Rats
Purpose: To investigate the effect of transcorneal electrical stimulation (TES) on the retina of wildtype Brown Norway (BN) rats by gene expression profiling. Methods: TES was applied to BN adult wildtype rat retina in vivo for 1h (1ms biphasic pulses at 20Hz; current: 200 M-BM-5A). RNA was isolated...
ORGANISM(S): Rattus norvegicus 
2011-11-21 | E-GEOD-26174 | biostudies-arrayexpress
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving and treatments with DNA methylation modifying drugs
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine, were subjected to 30 withdrawal days, were treated with aCSF, RG108 or SAM and were subjected to extinction tests. The groups consist of: 1. Rats that self-administered cocaine for 10 days and that were subjected...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66347 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat fetal kidney samples from offspring of hyperinsulinemic mothers
Inrauterine growth restriction was induced by chronic hyper insulinemia in pregnant rats and differential gene expression was studied using affymetrix rat genome RAE230A.Data was analysed using SAM. Experiment Overall Design: rna was isolated from 5 kidneys of growth restricted fetus and compared wi...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3215 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat colon exposed to soy or whey proteins
We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet)...
ORGANISM(S): Rattus norvegicus 
2009-04-30 | E-GEOD-6102 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver throughout the day
One µg of total RNA from either an; individual rat or from a pooled sample was amplified and labeled with a; fluorescent dye (either Cy3 or Cy5) using the Low RNA Input Linear Amplification Labeling kit (Agilent Technologies, Palo Alto, CA) following the manufacturerâ??s protocol. The amount and qu...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-2441 | biostudies-arrayexpress
TranscriptomicsFetal lung development
Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-3302 | biostudies-arrayexpress
TranscriptomicsCandidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats
The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol prefere...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15415 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat mesenteric lymph nodes upon supplementation with conjugated linoleic acid during gestation and suckling
A summary of the work associated to these microarrays is the following: Diet plays a role in the development of the immune system, and polyunsaturated fatty acids can modulate the expression of a variety of genes. Human milk contains conjugated linoleic acid (CLA), a fatty acid that seems to contri...
ORGANISM(S): Rattus norvegicus 
2011-07-21 | E-GEOD-23004 | biostudies-arrayexpress
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