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MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
TranscriptomicsTranscription profiling of rat liver samples treated with clofibrate, valproic acid and diethylhexylphthalate
The project had 2 goals:; 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Experiment Overall Design: Male SD rats were given a single dose of one of 3 prototypical toxica...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2303 | biostudies-arrayexpress
no omics definedTranscription profiling of rat liver pooled vs. individual samplesf rom a single-dose time-course rat study in response to the prototypical toxicants Clofibrate [CAS:637-07-0;CHEBI:3750], Diethylhexyl phthalate DEHP [CAS:117-81-7;CHEBI:17243], and valproic acid VPA [CAS:1069-66-5;CHEBI:9925],
Combining or pooling individual samples when carrying out transcript profiling using microarrays is a fairly common means to reduce both the cost and complexity of data analysis. However, pooling does not allow for statistical comparison of changes between samples and can result in a loss of informa...
ORGANISM(S): Rattus norvegicus 
2006-04-10 | E-TOXM-19 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Control vs. Kainate, scrambled ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were utilized to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled, and saline(controls) or kainate injections (induced status...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22896 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Control vs. Kainate, NRSE ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were utilized to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled or NRSE oligodeoxynucleotides, and saline(controls) or kain...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22894 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Kainate, NRSE ODNs vs. Kainate, scrambled ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were used to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled or NRSE oligodeoxynucleotides, and kainate injections (induced ...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22897 | biostudies-arrayexpress
TranscriptomicsDerivation of rat induced pluripotent stem cells that share similarities with embryonic stem cells using a transposon system
Induced pluripotent stem (IPS) cells have attracted enormous attention due to their vast potential in regenerative medicine, pharmaceutical screening and basic research. The majority of prior established rat IPS cells were generated from somatic cells by retroviral and lentiviral transduction with e...
ORGANISM(S): Rattus norvegicus 
2012-02-16 | E-GEOD-35841 | biostudies-arrayexpress
TranscriptomicsLevator Ani Satellite Cells (LASCs) treated with Nonsteroidal Androgen Receptor Agonist (NARA)
High regenerative capacity of adult skeletal muscle relies on a self-renewing depot of adult stem cells, termed muscle satellite cells (MSCs). A novel MSC line was isolated from the rat levator ani muscle and termed Levator Ani Satellite Cells (LASCs). Androgen, a known mediator of overall body com...
ORGANISM(S): Rattus norvegicus 
2014-11-20 | E-GEOD-63489 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22899 | biostudies-arrayexpress
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