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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsA Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression
This dataset contains RAW files from a large-scale survey of brain protein phosphorylation. It is part of a larger project that contains data from a large-scale survey of protein expression and phosphorylation encompassing nine mouse tissues: brain, brown fat, heart, kidney, liver, lung, pancreas, ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD019394 | Pride
Phosphoproteomics Map phosphoproteome 
TranscriptomicsUnique gene program of rat mesenteric arteries as revealed by Deep RNA Sequencing
This study used Deep RNA sequencing to define gene expression in the small resistance arteries and compare to a reference conduit artery, the aorta Methods: Deep RNA Sequencing (~90 million reads) was performed on 2 samples of adult SD rat mesenteric arteries and compared to that of 2 samples of aor...
ORGANISM(S): Rattus norvegicus 
2015-07-13 | E-GEOD-64450 | biostudies-arrayexpress
ProteomicsHLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery
Strazar M, Park J, Abelin JG, Taylor HB, Pedersen TK, Plichta DR, Brown EM, Eraslan B, Ortiz K, Clauser KR, Carr SA, Xavier RJ, Graham DB. 2022. T cell responses are exquisitely antigen-specific and directed against peptide epitopes displayed by human leukocyte antigen (HLA) on the surface of presen...
ORGANISM(S): Bifidobacterium Longum (ncbitaxon:216816) Veillonella Parvula (ncbitaxon:29466) Clostridium Clostridioforme 90a1 (ncbitaxon:999403) Bacteroides Thetaiotaomicron (ncbitaxon:818) Homo Sapiens (ncbitaxon:9606) Akkermansia Muciniphila (ncbitaxon:239935) Ruminococcus Gnavus Atcc 29149 (ncbitaxon:411470) 
2022-04-08 | MSV000089225 | MassIVE
ProteomicsMitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies
Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez A, Sun J, Baranowski K, Thompson PA, Heo J, Cartun Z, Aygun O, Notarangelo G, Livitz D, Li S, Hacken ET, Davids MS, Iorgelescu JB, Zhang W, Biran A, Fernandes SM, Brown JR, Ana Lako A, Ciantra ZB, Keskin DB, Udeshi ND, Wierd...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-02 | MSV000083512 | MassIVE
ProteomicsA Bidirectional Switch in the Shank3 Phosphorylation State Is Necessary to Enable Synaptic Scaling Up and Down
Wu C, Tatavarty V, Jean-Beltran PM, Guerrero A, Keshishian H, Krug K, MacMullan M, de Arce KP, Carr SA, Cottrell J, Turrigiano GG. 2021 Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of posttranslational modifications in th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-07-30 | MSV000087926 | MassIVE
TranscriptomicsDeletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure
The mammalian target of rapamycin complex 2 (mTORC2) contains the essential protein RICTOR and is activated by growth factors. mTORC2 in adipose tissue contributes to regulating glucose and lipid metabolism. In the perivascular adipose tissue (PVAT) mTORC2 ensures normal vascular reactivity by contr...
ORGANISM(S): Mus musculus 
2015-07-05 | E-GEOD-67077 | biostudies-arrayexpress
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Coronary Artery Risk Development in Young Adults (CARDIA)

CALiCo CARDIA
The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be appr...

phs000236.v1.p1 | EGA
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Atherosclerosis Risk in Communities (ARIC)

CALiCo ARIC
The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atheroscler...

phs000223.v1.p1 | EGA
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE)

By relating hundreds of thousands of genotypes to only a few phenotypes, mostly in individuals of one ancestry, genome-wide association (GWA) studies are identifying a rapidly growing number of associations. The Population Architecture using Genomics and Epidemiology (PAGE) Study is designed to f...

phs000356.v1.p1 | EGA
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