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TranscriptomicsBovine trophoblasts: control vs. infected with Brucella abortus
Brucellosis is still a widespread zoonotic disease. Very little is known about the interaction between B. abortus and trophoblastic cells, which is essential for better understanding the pathogenesis of the Brucella-induced placentitis and abortion, a key event for transmission of the disease. The g...
ORGANISM(S): Bos taurus 
2010-05-26 | E-GEOD-10342 | biostudies-arrayexpress
TranscriptomicsThe Brucella abortus general stress response system is required for chronic animal infection and exhibits noncanonical post-translational regulation
rpoE1 encodes an extracytoplasmic function (ECF) sigma factor to initiate the transcription of the genes responsible for general stress responses. This experiment is quantifying transcription in two Brucella strains: B. abortus 2308 wild type and rpoE1 in-frame deletion strains (gene bab1_1672).
ORGANISM(S): Brucella abortus 
2013-05-17 | E-MEXP-3722 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomic analysis of Brucella abortus and Brucella melitensis
Brucella type strains (B. abortus 544 and B. melitensis 16 M), field-isolates (B. abortus T and B. melitensis C) were independently cultivated six times on Tryptic Soy Broth at 37 °C in the presence of 5% CO2 until mid-logarithmic phase. The cells were harvested by brief centrifugation and the bacte...
ORGANISM(S): Brucella abortus Brucella melitensis 
2020-06-11 | PXD006348 | Pride
Label free quantitative analysis Perseus software Brucella abortus Brucella melitensis Maxquant-andromeda Comparative proteomic analysis Ltq orbitrap velos mass spectrometer Maxquant software 
TranscriptomicsTranscriptional changes produced in B. abortus by erythritol. RNAseq
The transcriptional changes produced in B. abortus by growth in the presence of erythritol have been analyzed by RNAseq. Erythrtol is a sugar believed to have a relation with the capability of Brucella to produce abortions in ruminants.
ORGANISM(S): Brucella abortus 
2013-05-03 | E-MTAB-1203 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify differentially expressed genes of intracellular Brucella abortus in RAW264.7 cells
Microarray analysis determined that 7.82% (244/3334) of Brucella abortus genes were up-regulated and 5.4% (180/3334) were down-regulated in RAW264.7 macrophages, compared to free-living bacteria in TSB In the study, Brucela abortus was isolated from infected macrophages at 24 post-infection, DNA mic...
ORGANISM(S): Brucella abortus str. 2308 A 
2013-04-30 | E-GEOD-46459 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of changes produced in Brucella abortus by erythriyol
RNA from B. abortus 2308 grown in BB or BB+ erythritol, was labelled and hybridized with the ORFeome microarray to determine transcriptional changes produced by erythritol
ORGANISM(S): Brucella abortus 
2013-05-03 | E-MTAB-1189 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Stationary Growth Stage and Nutritional Deficiency Adaptation Reveals Brucella Abortus Virulence Mechanisms
Brucellosis, an important bacterial zoonosis caused by Brucella species, has drawn increased attention around the world. As an intracellular pathogen, the ability of Brucella to deal with stress within the host cell is closely related to its virulence. The survival pressure on Brucella within a phag...
ORGANISM(S): Brucella abortus str. 2308 A 
2021-09-09 | PXD020869 | Pride
B. abortus  proteomics  logarithmic phase  stationary phase  nutritional stress 
TranscriptomicsGlobal gene transcriptional profiles of RAW 264.7 cells following the infection with Brucella abortus wild and mutant strains
We focused on whether transposon mutagenesis in Brucella abortus could induce difference in the trascriptional responses of RAW 264.7 cell infection model compared to the wild strain infected RAW 264.7 cells. The function of genes in Brucella abortus was analyzed through the identified differences i...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79264 | biostudies-arrayexpress
GenomicsBrucella abortus ChipSeq analysis of BvrR
Brucella abortus ChipSeq analysis of BvrR
ORGANISM(S): Brucella abortus 
2020-11-10 | E-MTAB-9740 | biostudies-arrayexpress
TranscriptomicsExpression Data from Brucella abortus strain 2308 and isogenic mucR mutant cells
MucR is one of the few transcriptional regulatory proteins that has been linked to Brucella pathogenesis. We used custom-made Affymetrix B. abortus strain 2308 derived GeneChips to copare the gene expression properties of wild type and isogenic mucR mutant cells. B. abortus strain 2308 or mucR mutan...
ORGANISM(S): Brucella abortus 
2012-12-01 | E-GEOD-40532 | biostudies-arrayexpress
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