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TranscriptomicsModeling the clinical phenotype of BTK inhibition in the mature murine immune system
Using the novel BTK inhibitor PF-303, we model the clinical phenotype of BTK inhibition by systematically examining the impact of PF-303 on the mature immune system in mice autoimmune indications. However, our current knowledge of the role of BTK in immune competence has been gathered in the context...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-56483 | biostudies-arrayexpress
TranscriptomicsRole of IL-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) in mast cell response to lipopolysaccharide (LPS)
Mast cells are indispensable for LPS-induced septic hypothermia, in which TNF-α plays an essential role to initiate sepsis. Tec family non-receptor tyrosine kinases ITK and BTK regulate mast cell-derived TNF-α in response to allergic antigen, but their role in LPS-induced TNF-α production by mast...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-64287 | biostudies-arrayexpress
ProteomicsImpact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Inhibition of Bruton’s tyrosine kinase (BTK) has proven to be highly effective in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL), autoimmune disorders and multiple sclerosis. Since the approval of the first BTK inhibitor (BTKi), Ibrutinib, several other inhibitors in...
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD047865 | Pride
Bruton’s tyrosine kinase  kinase inhibitor  drug resistance  allostery  sh2 domain  hydrogen deuterium exchange  hdx-ms 
TranscriptomicsModeling the clinical phenotype of BTK inhibition in the mature murine immune system
Using the novel BTK inhibitor PF-303, we model the clinical phenotype of BTK inhibition by systematically examining the impact of PF-303 on the mature immune system in mice autoimmune indications. However, our current knowledge of the role of BTK in immune competence has been gathered in the context...
ORGANISM(S): Mus musculus 
2014-08-01 | GSE56483 | GEO
GenomicsBTK inhibition prevents microglia-mediated demyelination induced by multiple sclerosis patient antibodies
BTK inhibition prevents microglia-mediated demyelination induced by multiple sclerosis patient antibodies
PRJNA1465288 | ENA
GenomicsAllosteric inhibition of proteolytic and ATPase activities of the proteasome by the BTK inhibitor CGI-1746
Allosteric inhibition of proteolytic and ATPase activities of the proteasome by the BTK inhibitor CGI-1746
PRJNA999365 | ENA
GenomicsEffect of BTK and GSK3 inhibition on gene expression in primary peripheral human B cells
Effect of BTK and GSK3 inhibition on gene expression in primary peripheral human B cells
PRJNA848850 | ENA
GenomicsBTK drives neutrophil activation for sterilizing antifungal immunity
BTK drives neutrophil activation for sterilizing antifungal immunity
PRJNA1020829 | ENA
UnknownThe Immunomodulatory Mechanisms of BTK Inhibition in CLL and Beyond.
Not available
S-EPMC11545099 | biostudies-literature
ProteomicsExceptional Response to BTK Inhibitors in Aggressive Lymphomas Linked to Chronic Selective Autophagy
Diffuse large B cell lymphoma is an aggressive cancer type that is profoundly heterogeneous, both molecularly and phenotypically, presenting a challenge for precision medicine. Inhibitors of the kinase BTK block B cell receptor (BCR)-dependent NF-ï«B signaling and are particularly effective in cert...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041092 | Pride
Funtional proteogenomics Dlbcl Selective autophagy Btk inhibition 
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