Sort   by:  
 Page size 
TranscriptomicsTimecourse of doxycycline induction in bitransgenic MTB/TAN, MTB/TOM, and MTB/TWNT1 mice or monotransgenic MTB control mice
Genome-wide expression data can provide important insights into normal and pathological cellular processes. However, the ability to use gene expression data to quantitatively assess the activation state of a given signaling pathway or transcriptional network in a sensitive and specific manner remai...
ORGANISM(S): Mus musculus 
2013-09-18 | E-GEOD-50969 | biostudies-arrayexpress
ProteomicsSubstrate Identification Using a Chemical Genetics Approach Reveals a Role for PARP-7-Mediated MARylation in Controlling Microtubule Stability in Ovarian Cancer Cells
To identify the ADPRylated substrates that underlie PARP-7-mediated ovarian cancer cell phenotypes, we developed an NAD+ analog-sensitive approach for PARP-7 comprising a PARP-7 NAD+ binding pocket mutant (S563G) paired with the NAD+ analog 8-Bu(3-yne)T-NAD+. When coupled with mass spectrometry, th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-17 | MSV000086611 | MassIVE
TranscriptomicsBmpr2 mutation in murine PMVEC
Pulmonary arterial hypertension (PAH) is thought to be driven by dysfunction of pulmonary vascular microendothelial cells (PMVEC). Most hereditary PAH is associated with BMPR2 mutations. However, the physiologic and molecular consequences of expression of BMPR2 mutations in PMVEC are unknown. PMVEC ...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-28043 | biostudies-arrayexpress
GenomicsCooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We val...
ORGANISM(S): Drosophila virilis 
2014-10-20 | E-GEOD-60428 | biostudies-arrayexpress
TranscriptomicsCooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species (GSE60428) and HiC analysis in Drosophila melanogaster. We demonstrate an extremely high conservation of Polyc...
ORGANISM(S): Drosophila melanogaster 
2014-10-20 | E-GEOD-61471 | biostudies-arrayexpress
TranscriptomicsRNA-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15856 | biostudies-arrayexpress
TranscriptomicsATAC-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15871 | biostudies-arrayexpress
TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
TranscriptomicsMosaic perturbation of transcription factors in human retinal organoid development
To begin to understand how TFs regulate retinal cell type identity in human tissues, we established a pooled loss of function (LOF) experiment based on the CROP-seq protocol in developed retinal organoids. We targeted five TFs (OTX2, NRL, CRX, VSX2, and PAX6) that are important for retinal developme...
ORGANISM(S): Homo sapiens 
2023-02-24 | E-MTAB-12622 | biostudies-arrayexpress
Sort   by:  
 Page size