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TranscriptomicsExamining smoking-induced differential gene expression changes in buccal mucosa
A tissue like buccal mucosa (from cheek swabs) would be an ideal sample material for rapid, easy collection for testing of biomarkers as an alternative to blood. A limited number of studies, primarily in the smoker/oral cancer literature, address this tissue's efficacy for quantitative PCR or micro...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-16149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal and transformed buccal keratinocytes
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein level. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-sc...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7862 | biostudies-arrayexpress
ProteomicsHuman buccal cell LC-MS/MS Pilot and LFQ
Proteomics analysis of buccal cells from patients with schizophrenia and matched control subjects.
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD055067 | Pride
Human Schizophrenia Buccal cell 
TranscriptomicsBuccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Illumina tiling]
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. Howeve...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-46573 | biostudies-arrayexpress
TranscriptomicsBuccal epithelial gene expression in smoky and smokeless coal users
Exposure to indoor air pollution generated from the combustion of solid fuels is a major risk factor for a spectrum of cardiovascular and respiratory diseases, including lung cancer. In China’s rural counties of Xuanwei and Fuyuan, lung cancer rates are among the highest in the country. While the ...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-64277 | biostudies-arrayexpress
GenomicsBuccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Bisulfite-Seq]
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. Howeve...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-46572 | biostudies-arrayexpress
TranscriptomicsDistinct DNA methylation patterns of cognitive impairment and Trisomy 21 in Down Syndrome
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer’s Disease (AD). While the mechanism underlying these changes is unknown, it has been hy...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50586 | biostudies-arrayexpress
ProteomicsEpi-proteomic assessment of backpain therapy
This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices. We report that the therapy improves agility, attenuates backpain, and also triggers healthier habits. We find that a subset of participants´ histone methylation and a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-21 | PXD050113 | Pride
Pbmc Histone ptms Buccal swabs Proteome Backpain therapy 
TranscriptomicsCigarette smoke exposure of human organotypic cultures of buccal and gingival mucosa
Oral mucosa of smokers is subject to cigarette smoke (CS)-related cytological, genomic, and transcriptional changes that could potentially lead to the development of mouth diseases. In order to further characterize CS effects, we took advantage of two human organotypic in vitro models of the buccal ...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-MTAB-2251 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human buccal and nasal epithelium of current and never smokers
Smoking is the leading cause of lung cancer death, although only a small percentage of smokers develop the disease. Cigarette smoke exposure is known to cause a field of injury in cells throughout the respiratory tract, and while these airway epithelial cells are morphologically normal, they can und...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-8987 | biostudies-arrayexpress
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