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TranscriptomicsContinuous T cell receptor signals maintain a functional regulatory T cell pool
During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become regulatory T (Treg) cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inhe...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-62532 | biostudies-arrayexpress
TranscriptomicsB cell-intrinsic STAT6 controls the germinal center response in type 2 immunity
By investigating the germinal center (GC) formation in STAT6ko/WT bone marrow-mixed chimera we found that GC formation in type 2 immune responses is dependent on B cell intrinsic expression of IL-4/IL-13-induced genes. We therefore used microarrays to find Stat6 dependent genes that are important fo...
ORGANISM(S): Mus musculus 
2014-05-26 | E-GEOD-47679 | biostudies-arrayexpress
ProteomicsComparing different pregnant mare serum gonadotropin products: surprising differences in protein content and a new sialic acid O-acetylation
Equine chorionic gonadotropin (eCG) is a widely used hormone to synchronize the female cycle and induce estrusestruses in livestock breeding. eCG is a heterodimeric glycoprotein composed of non-covalently linked α- and β-chains whose glycosylation profiles determine the in vivo activity of the hormo...
ORGANISM(S): Equus caballus (Horse) 
2025-05-06 | PXD042535 | Pride
O-acetylation Equine chorionic gonadotropin (ecg) and lutropin Pregnant mare serum gonadotropin (pmsg) Sulfation 
TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
TranscriptomicsLymphotoxin-beta receptor activation in HBV-infected HepaRG cells
The objective of this experiment was to test the effect, at a transcrptomic level, of lymphotoxin-beta receptor activation in HBV-infected differentiated HepaRG cells 4 biological replicates per condition were analyzed
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-46667 | biostudies-arrayexpress
TranscriptomicsGene expression data from CD4pos human childhood study
Reveal differentially regulated genes and cellular pathways within allergic and non-allergic asthmatic children compared to healthy controls CD4pos cells were obtained from allergic asthmatics, non-allergic asthmatics and healthy controls and kept without stimulation.
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-40887 | biostudies-arrayexpress
TranscriptomicsGene expression data from PBMCs human childhood study
Reveal differentially regulated genes and cellular pathways within allergic and non-allergic asthmatic children compared to healthy controls Peripheral blood mononuclear cells (PBMCs) were obtained from allergic asthmatics (n=14), non-allergic asthmatics (n=8) and healthy controls (n=14) and kept wi...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-40888 | biostudies-arrayexpress
TranscriptomicsMicroarray-based identification of signalling pathways and biomarkers in allergic and non-allergic asthma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-40889 | biostudies-arrayexpress
TranscriptomicsHost microbiota constantly control maturation and function of microglia in the central nervous system (part 2)
As tissue macrophages of the central nervous system (CNS), microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. Here we reveal significant contributions of the host microbiota to microglia ho...
ORGANISM(S): Mus musculus 
2015-05-25 | E-GEOD-67857 | biostudies-arrayexpress
TranscriptomicsHigh-fat diet-mediated dysbiosis cooperates with oncogenic K-Ras activation to promote intestinal carcinogenesis independently of obesity.
Several aspects of a Western lifestyle such as increased obesity and decreased physical activity are associated with increased risk for gastrointestinal cancers1. Although high-fat diet (HFD) induced low-grade inflammation has been closely linked to tumorigenesis2, however, the microbial shift that ...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-42840 | biostudies-arrayexpress
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