Sort   by:  
 Page size 
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
ProteomicsSemi-Synthesis of an Evasin from Tick Saliva Reveals a Critical Role of Tyrosine Sulfation for Chemokine Binding and Inhibition
Blood feeding arthropods produce anti-inflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signalling in the host. Herein, we show that the evasin ACA-01 from the Amblyomma cajennense tick can be post-translationally sulfated at two tyrosine residues, ...
ORGANISM(S): Amblyomma cajennense 
2020-05-15 | PXD016778 | Pride
Synthetic Chemokine Evasin Sulfation 
ProteomicsSearching for Sulfotyrosines (sY) in a H A( pY ) STACK
Protein sulfation can be crucial in regulating protein-protein interactions but remains largely underexplored. Sulfation is near-isobaric to phosphorylation, making it particularly challenging to investigate using mass spectrometry. The degree to which tyrosine sulfation (sY) is misidentified as pho...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059650 | Pride
Tyrosine sulfation Proteomics Misidentification Large scale meta - analysis Phosphorylation Mass spectrometry 
ProteomicsInstallation of O-glycan sulfation capacities in human HEK293 cells
The human genome contains at least 35 genes that encode Golgi sulfotransferases functioning in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. Our insight into the sulfotransferases that serve glycoproteins and in p...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD028982 | Pride
Muc1 Sulfated-t Glycosylation Sulfation Sulfated-tn O-glycans 
ProteomicsA bespoke analytical workflow for the identification of sulfopep-tides and confident discrimination from phosphopeptides_C4PR_LIV
Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalysed by Golgi-resident Tyrosyl Protein Sul-foTransferases (TPSTs). Information on protein tyrosine sulfation is currently limited to ~50 human proteins with only a handful of those having verified sites of sulfation. The...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043723 | Pride
Tyrosine-o-sulfation Sulfotyrosine Sulfation 
ProteomicsA bespoke analytical workflow for the identification of sulfopep-tides and confident discrimination from phosphopeptides_C4PR_LIV
Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalysed by Golgi-resident Tyrosyl Protein Sul-foTransferases (TPSTs). Information on protein tyrosine sulfation is currently limited to ~50 human proteins with only a handful of those having verified sites of sulfation. The...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043713 | Pride
Tyrosine-o-sulfation Sulfotyrosine Sulfation 
GenomicsExtracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasiveness
Extracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasiveness
PRJNA1141167 | ENA
ProteomicsElectron Capture vs. Transfer Dissociation for Site Determination of Tryptic Peptide Tyrosine Sulfation: Direct Detection of Fibrinogen Sulfation Sites and Identification of Novel Isobaric Interferences
Tyrosine sulfation is an understudied posttranslational modification (PTM) of crucial biological significance. Conventional liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods are unable to directly identify sulfation sites due to the high lability of the sulfate PTM. In this study, we...
ORGANISM(S): Bos taurus (Bovine) 
2024-06-21 | PXD048811 | Pride
Post-translational modifications Mass spectrometry Direct determination Tyrosine sulfation Proteomics. 
GenomicsGut Microbiota Metabolite Indole-3-Acetic Acid Maintains Intestinal Epithelial Homeostasis Through Mucin Sulfation
Gut Microbiota Metabolite Indole-3-Acetic Acid Maintains Intestinal Epithelial Homeostasis Through Mucin Sulfation
PRJNA1051583 | ENA
GenomicsTargeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss
Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss
PRJNA974428 | ENA
Sort   by:  
 Page size