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TranscriptomicsTranscription profiling of rat 3Y1 embryonic fibroblasts to identify MUC1-induced transcriptional alterations
The MUC1 oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer. Although MUC1 modulates the activity of several transcription factors, there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of M...
ORGANISM(S): Rattus norvegicus 
2009-04-19 | E-GEOD-14337 | biostudies-arrayexpress
TranscriptomicsMicroRNAs differentially expressed in MUC1 overexpressing cells
To determine if overexpression of MUC1 alters the microRNA profile of pancreatic cancer cells S2.013. Comparison of miRNAs differentially regulated in pancreatic cancer cell line S2.013 with and without MUC1 overexpression. MiRCURY LNA microarray was used to determine differential microRNA expressio...
ORGANISM(S): Homo sapiens 
2013-08-10 | E-GEOD-48185 | biostudies-arrayexpress
ProteomicsMUC1(insC) affects vesicular transport in renal epithelial cells
Autosomal dominant tubulointerstitial kidney disease associated to the MUC1 gene (ADTKD-MUC1; formerly MCKD1) belongs to a heterogenous group of rare hereditary kidney diseases that is prototypically caused by frameshift mutations in the MUC1 repeat domain. The mutant MUC1(insC) lacks the transmembr...
ORGANISM(S): Homo sapiens (Human) 
2018-02-23 | PXD008389 | Pride
Exosomes Adtkd-muc1 / mdck1 / vesicular transport / multivesicular bodies 
TranscriptomicsExpression of genes in the spleen of WT and MUC1.Tg mice immunized with dendritic cells loaded with MUC1 peptide
Goal of study: To determine differentially expressed genes with potential roles in tolerance and immunity in MUC1-immunized WT and MUC1.Tg mice WT (C57Bl/6) and MUC1.Tg mice were immunized (i.v.) with dendritic cells loaded with sythetic, human MUC1 peptide. At 24h and 72h splenic RNA from vaccinati...
ORGANISM(S): Mus musculus 
2013-01-16 | E-GEOD-43503 | biostudies-arrayexpress
TranscriptomicsImpact of E2 ubiquitin conjugating activity of MUC1 on gene expression
We identified a novel E2 ubiquitin conjugating activity within the C-terminus domain of MUC1. To determine if E2 ubiquitin conjugating activity of MUC1 is responsible for regulating expression of oncogenic genes we isolated RNA from vector control cells, MUC1 wildtype overexpression cells, and cell...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-60339 | biostudies-arrayexpress
TranscriptomicsHuman renal clear-cell carcinoma cells : control vs MUC1 overexpressing cells
Transcriptional profiling of human renal clear-cell carcinoma cells comparing control unexpressing MUC1 cells (82-F7 and 82-65 samples) with MUC1 overexpressing cells (83-2 and 83-5 samples) Goal was to determine the effect of MUC1 expression on global gene expression
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-49594 | biostudies-arrayexpress
TranscriptomicsIdentification of differential gene expression modulated by knockdown of MUC1 in MKN45 gastric carcinoma cells
Transcripts upregulated or downregulated by knockdown of MUC1 were identified through expression profiling of a total of 12,135 genes in comparison with MKN45- MUC1 RNAi clones and control clones. We endeavored to identify genes which expression is affected by MUC1 by performing cDNA microarray anal...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-28975 | biostudies-arrayexpress
TranscriptomicsGene regulation during colitis-associated colon cancer in Muc1 hematopoietic KO chimeric mice
MUC1 is a tumor-associated antigen that is aberrantly expressed in cancer and inflammatory bowel disease (IBD). Even though immune cells express low MUC1 levels, their modulations of MUC1 are important in tumor progression. Consistent with previous clinical data that show increased myeloid-derived s...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-47487 | biostudies-arrayexpress
ProteomicsSequencing the anti-MUC1 hybridoma antibody 139H2
Mucin 1 (MUC1) is a transmembrane mucin expressed at the apical surface of epithelial cells at different mucosal surfaces including breast and intestine. The MUC1 extracellular domain contains a variable number of tandem repeats (VNTR) of 20 amino acids, which are heavily O-linked glycosylated. Mono...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD043489 | Pride
Muc1 Antibody Hybridoma De novo 
GenomicsMUC1 triggers lineage plasticity of Her2 positive mammary tumor
MUC1 triggers lineage plasticity of Her2 positive mammary tumor
PRJNA814266 | ENA
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