Blood feeding arthropods produce anti-inflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signalling in the host. Herein, we show that the evasin ACA-01 from the Amblyomma cajennense tick can be post-translationally sulfated at two tyrosine residues, ...
We use HDX-MS to characterise the binding interface between the tick evasin P672 and the chemokine CCL8, in order to assist in the development of peptides capable of mimicking P672 anti-inflammatory activity.
