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TranscriptomicsTpl2 promotes chemokine/chemokine receptor expression and macrophage migration during acute inflammation
In autoimmune diseases, accumulation of activated leukocytes correlates with inflammation and disease progression, and therefore, disruption of leukocyte trafficking is an active area of research. The protein kinase Tpl2 (MAP3K8) regulates leukocyte inflammatory responses and is also being investig...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-48338 | biostudies-arrayexpress
TranscriptomicsThe transcriptional repressor BLIMP1 curbs host-defenses by suppressing expression of the chemokine CCL8
The transcriptional repressor BLIMP1 is a master regulator of B and T cell differentiation. To examine the role of BLIMP1 in innate immunity we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection induced by Listeria monocyt...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53145 | biostudies-arrayexpress
ProteomicsEndosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
Chemokine receptors are GPCRs that regulate chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors harbor molecular properties, which are associated with an ability to stimulate G proteins during b-arrestin-mediated internalization into endosomes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090362 | MassIVE
TranscriptomicsGene expression profiling of chemokines and chemokine receptors on B-cells in chronically HIV-1 infected patients
From the analysis of all genes included in the array a number of individual genes were identified as dys-regulated in HIV-1 infected patients compared to healthy controls. In particular, increased CXCL13 expression in all individual patient samples. Abstract from publication: HIV-1 infection is ass...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12597 | biostudies-arrayexpress
ProteomicsSemi-Synthesis of an Evasin from Tick Saliva Reveals a Critical Role of Tyrosine Sulfation for Chemokine Binding and Inhibition
Blood feeding arthropods produce anti-inflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signalling in the host. Herein, we show that the evasin ACA-01 from the Amblyomma cajennense tick can be post-translationally sulfated at two tyrosine residues, ...
ORGANISM(S): Amblyomma cajennense 
2020-05-15 | PXD016778 | Pride
Synthetic Chemokine Evasin Sulfation 
UnknownPlacental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
Not available
S-EPMC6557524 | biostudies-literature
UnknownChemokine receptors coordinately regulate macrophage dynamics and mammary gland development.
Not available
S-EPMC7328164 | biostudies-literature
UnknownInternational Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Not available
S-EPMC3880466 | biostudies-literature
UnknownChemokine Receptor Redundancy and Specificity Are Context Dependent.
Not available
S-EPMC6382461 | biostudies-literature
UnknownThe Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
Not available
S-EPMC6176105 | biostudies-literature
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