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ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
2023-10-16 | PXD038532 | panorama
ModelsSen2021 - HTimmR - A generic human CD4+ T-cell model
A generic genome-scale metabolic model (GEMs) of human CD4+ T-cells. Several cell-specific GEMs for CD4+ T-cell subsets such as Th1, Th2, Th17 and iTreg cells derived from "HTimmR" are included as additional files. The model formats are compatible with RAVEN v.2.0 toolbox.
2023-03-29 | MODEL2101270002 | BioModels
ProteomicsProteome screening of Bacillus cereus derived extracellular vesicles
Extracellular vesicles (EVs) from Gram-positive bacteria have gained considerable importance as a novel transport system of virulence factors in host-pathogen interactions. Bacillus cereus is a Gram-positive human pathogen, causing gastrointestinal toxemia as well as local and systemic infections. T...
ORGANISM(S): Bacillus cereus 
2023-07-20 | PXD041561 | Pride
Proteomics Bacillus cereus Extracellular vesicles 
ProteomicsProteomics reveals the essential role for LPXN in human iTreg suppression
Regulatory T cells are critical in the modulation of immune responses. Accordingly, the manipulation and implementation of in vitro induced Treg cells to control immune function has a significant potential in clinical medicine. However, the use of iTregs as therapeutics is complicated by their poor ...
ORGANISM(S): Homo Sapiens 
2026-08-27 | PXD052690 | panorama
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