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TranscriptomicsFLT3 gene-expression signature in normal karyotype AML
Acute myeloid leukemia with normal karyotype (NK-AML) represents a cytogenetic grouping with intermediate prognosis but substantial molecular and clinical heterogeneity. Within this subgroup, presence of FLT3 (FMS-like tyrosine kinase 3) internal tandem duplication (ITD) mutation predicts less favo...
ORGANISM(S): Homo sapiens 
2008-02-27 | E-GEOD-8043 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of myeloid leukemia cell lines
Cell lines. The myeloid cell lines CMK, HEL, HL-60, K-562, KASUMI-1, KG-1, LAMA-84, M-07e, MONO-MAC-1, MV4-11, NB-4, OCI-AML2, OCI-AML5, SIG-M5, THP-1, and UT-7 were obtained from the DSMZ in Braunschweig, Germany (http://www.dsmz.de). The cell line ME-1 was kindly provided by Dr. Ikuya Sakai, Ehim...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-8779 | biostudies-arrayexpress
TranscriptomicsGene expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia.
Core binding factor (CBF) leukemias, characterized by either inv(16)/t(16;16) or t(8;21), constitute acute myeloid leukemia (AML) subgroups with favorable prognosis. However, there exists substantial biological and clinical heterogeneity within these cytogenetic groups, which is not fully reflected ...
ORGANISM(S): Homo sapiens 
2007-08-09 | E-GEOD-8653 | biostudies-arrayexpress
TranscriptomicsAnalysis of MYC in murine lymphoma cell lines
This SuperSeries is composed of the following subset Series: GSE12278: MYC stimulates EZH2 expression by repression of its negative regulator miR-26a GSE12394: murine MYC-dependent lymphoma cells: Dox vs. NoDox treatment Refer to individual Series
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12400 | biostudies-arrayexpress
Transcriptomicsmurine MYC-dependent lymphoma cells: Dox vs. NoDox treatment
miRNA expression profiling of murine MYC-dependent lymphoma cell lines harboring the MYC-transgene in a Tet-off system comparing control untreated lymphoma cells (high MYC expression state) with 18hours Dox treated lymphoma cells (low MYC expression state). Keywords: inducible expression system Two...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12394 | biostudies-arrayexpress
TranscriptomicsCommon and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias.
In this report we demonstrate that the ability to alter self-renewal in vitro and in vivo is a more generalized property of leukemia-associated oncogenes. We further demonstrate that disparate leukemia-associated oncogenes initiate early common and overlapping transformation and self-renewal gene ex...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-23143 | biostudies-arrayexpress
TranscriptomicsLAA expression profiles on LSC compared to other tissues
Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. Leukemia associated antigens (LAA) might be suitable structures to be attacked by immunotherapeutic age...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-68172 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML
In acute myeloid leukemia (AML) non-random clonal chromosome aberrations are detectable in ~55% of adults with AML. Translocation t(8;21)(q22;q22) resulting in the 5'RUNX1/3'RUNX1T1 fusion gene occurs in ~8% of acute myeloid leukemia (AML) cases. Also, insertions ins(8;21) and ins(21;8) have been de...
ORGANISM(S): Homo sapiens 
2010-10-26 | E-GEOD-24384 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model.
Data underlying Sander et al., Oncogene 2005, June 20, Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model. Includes both array CGH and expression data. Abstract: Microarray-based formats offer a high-resolution alternative to conventional, chr...
ORGANISM(S): Mus musculus 
2006-01-24 | E-GEOD-4092 | biostudies-arrayexpress
TranscriptomicsRUNX1 mutated cases in acute myeloid leukemia share a distinct biological subgroup and are associated with inferior outcome. Results of the AML Study Group (AMLSG).
PURPOSE: To evaluate frequency, biological features and clinical relevance of RUNX1 mutations in acute myeloid leukemia (AML). PATIENTS AND METHODS: Diagnostic samples from 945 patients (18 to 60 years) were analyzed for RUNX1 mutations. In a subset of cases (n=269) microarray gene expression analy...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-23312 | biostudies-arrayexpress
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