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ProteomicsMetabolic enhancement of developmental pausing (embryos)
Embryonic stem (ES) cells and embryos reversibly pause via chemical mTOR inhibition. In this study, we investigate the tissue-specific response to mTORi-induced pausing in ES and trophoblast stem (TS) cells. To resolve the sequential rewiring of the proteome, we conducted a time-series proteomics ex...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-06 | PXD041325 | Pride
Pluripotency Mtor inhibition Embryonic stem cells Embryonic diapause 
ProteomicsCoordinated miRNA activity mediates the cellular transition into dormancy during embryonic diapause
Dormancy is a key feature of stem cell function in adult tissues as well as embryonic cells in the context of diapause. The establishment of dormancy is an active process that involves extensive transcriptional, epigenetic, and metabolic rewiring. How these processes are coordinated to successfully ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-03-26 | PXD044550 | Pride
Embryonic diapause 
ProteomicsmTOR activity paces human blastocyst stage developmental progression (data set 2)
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway1. It is unknown whether this ability is conserved in mamma...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-26 | PXD036258 | Pride
Pausing embryonic development 
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
GenomicsA transcription factor based mechanism for mouse heterochromatin formation
We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is ...
ORGANISM(S): Mus musculus 
2012-09-16 | E-GEOD-40086 | biostudies-arrayexpress
ProteomicsHypoxia induces a transcriptional primitive streak signature in ES cells and enhances lineage patterning in gastruloids
The cellular microenvironment shapes stem cell identity and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and benefit from hypoxic culture in vitro. Yet, how different components of the hypoxia response impact stem cell transcriptional networks and lineage choices ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-05 | PXD026641 | Pride
Embryonic stem Hypoxia Early embryos 
ProteomicsTET activity propagates transcriptional memory through embryonic dormancy
Dormancy is an essential biological process for the propagation of many life forms through generations and stressful conditions. Early embryos of many mammals are preservable for weeks to months within the uterus under dormancy, which can be induced in vitro through mTOR inhibition. Dormancy feature...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-22 | PXD039056 | Pride
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ProteomicsmTOR activity paces human blastocyst stage developmental progression (data set 1)
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway1. It is unknown whether this ability is conserved in mamma...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-06 | PXD029513 | Pride
Diapause Pluripotency Dormancy 
ProteomicsMetabolic enhancement of developmental pausing (ES dataset)
Embryonic stem (ES) cells and embryos reversibly pause via chemical mTOR inhibition. In this study, we investigate the tissue-specific response to mTORi-induced pausing in ES and trophoblast stem (TS) cells. To resolve the sequential rewiring of the proteome, we conducted a time-series proteomics ex...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-06 | PXD033750 | Pride
Pluripotency Mtor inhibition Embryonic stem cells Embryonic diapause 
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