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TranscriptomicsRNA-seq in breast cancer cell lines after manipulation of miR-23b expression
RNA sequencing technology has been carried out in order to evaluate mRNA expression changes after manipulation of miR-23b in both MCF-7 and MDA-MB-231 breast cancer cell lines Our study implicates miR-23b in cytoskeletal remodeling in breast cancer. To evaluate the entire set of genes modulated by m...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37918 | biostudies-arrayexpress
UnknownThe responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.
Not available
S-EPMC5701047 | biostudies-literature
ProteomicsLMTK3 Represses Tumour Suppressor-Like Genes through Chromatin Remodeling in Breast Cancer
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer including breast, lung, gastric and colorectal. It is localized in different cellular compartments but its nuclear function has not been investigated thus far. We have mapped LMTK3 binding across the genome us...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD002399 | Pride
Lmtk3 chromatin breast cancer 
UnknownCDK7 inhibitors as anticancer drugs.
Not available
S-EPMC7497306 | biostudies-literature
GenomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [ChIP-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78284 | biostudies-arrayexpress
UnknownCharacterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells.
Not available
S-EPMC3821059 | biostudies-literature
TranscriptomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [RNA-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78285 | biostudies-arrayexpress
UnknownResistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells.
Not available
S-EPMC12528448 | biostudies-literature
GenomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78286 | biostudies-arrayexpress
UnknownLRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.
Not available
S-EPMC4737183 | biostudies-literature
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