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TranscriptomicsGene expression from human prefrontal cortex (BA46)
Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis of postmortem brains of patients with BD or SZ, and examined expression patterns of mitochondria-related genes...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12649 | biostudies-arrayexpress
TranscriptomicsGenotyping of human cell lines with amplification of single cell vs. non amplied products to examime the effect of allele bias during amplification
Single-cell human genome analysis using whole-genome amplified product is hampered by allele bias during amplification. Using an oligonucleotide SNP array, we examined the nature of the allele bias and its effect on the chromosomal copy number analysis. Experiment Overall Design: TB106, lymphoblasto...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8567 | biostudies-arrayexpress
TranscriptomicsEvaluation of the whole genome amplification of bisulfite modified DNA
We compared genom-wide DNA methylation profiles between whole genome amplified bisufite-modified DNA and non-amplified DNA. 3 samples were bisulfite-converted, non-amplified DNA (technical triplicate). 6 samples were amplified with EpiTect® Whole Bisulfitome from 10ng or 50ng of bisulfite-converted ...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-39565 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of brain between human and chimpanzee
Genome wide DNA methylation profiling of brain and liver from human and chimpanzee. The Illumina HumanMethylation27 DNA Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs for each sample. Samples included liver and NeuN-positive/NeuN-negative/unsorted brain in...
ORGANISM(S): Pan troglodytes 
2015-06-19 | E-GEOD-38804 | biostudies-arrayexpress
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