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TranscriptomicsTranscription profiling of DeltaNp73 alpha expressing C2C12 myoblasts examined 6 and 24 hours after shifting the cells to a differentiation medium to study the functions of the individual members of P53 family.
The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5447 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human H1299 cellls transformed with different p73/p53 constructs shows C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
The p53 family is known as a family of transcription factors with functions in tumor suppression and development. Whereas the central DNA binding domain is highly conserved among the three family members p53, p63 and p73, the C-terminal domains (CTDs) are diverse and subject to alternative splicing ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8660 | biostudies-arrayexpress
TranscriptomicsTumor biopsies from 71 untreated patients with mantle cell lymphoma
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Keywords: lymphochip; MCL; untreated Tumor biopsies from 71 untreated patients with mantle cell lymphoma
ORGANISM(S): Homo sapiens 
2010-05-23 | E-GEOD-10793 | biostudies-arrayexpress
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