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ProteomicsMultiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD026263 | Pride
Foxo signalling Post-translational modification Icat Structural biology Intrinsically disordered proteins Nmr spectroscopy Transcription factors Wnt signalling -catenin Phosphorylation 
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
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