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ProteomicsBSO and Auranofin Redox ICAT: Dataset of peptide identification results from a Redox ICAT experiment including rawfiles from LTQ-Orbitrap XL
In the current study, we used a mass spectrometry-based redox proteomics approach to test responses of the cysteine (Cys) proteome to selective disruption of the Trx- and GSH-dependent systems. Auranofin (ARF) was used to inhibit Trx reductase without detectable oxidation of the GSH/GSSG couple, and...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD000353 | Pride
Bso Auranofin Mass spectrometry Redox Icat Proteomics 
UnknownE2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT.
Not available
S-EPMC7225968 | biostudies-literature
ProteomicsLens Disulfide crosslink
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-07-20 | MSV000079952 | MassIVE
ProteomicsLens Disulfide crosslink - Evidence of highly conserved β-crystallin disulfidome that can be mimicked by in vitro oxidation in age-related human cataract and glutathione depleted LEGSKO mouse lens
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2015-10-16 | PXD002658 | Pride
Cataract Lens Disulfide bond 
UnknownOpposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation.
Not available
S-EPMC5642527 | biostudies-literature
UnknownICAT: a novel algorithm to robustly identify cell states following perturbations in single-cell transcriptomes.
Not available
S-EPMC10172037 | biostudies-literature
UnknownStructure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity.
Not available
S-EPMC5342195 | biostudies-literature
UnknownInhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
Not available
S-EPMC316784 | biostudies-literature
UnknowniCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencing.
Not available
S-EPMC8276190 | biostudies-literature
UnknownICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.
Not available
S-EPMC9551128 | biostudies-literature
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