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MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
MetabolomicsGut microbiota dysbiosis and altered fecal metabolome in patients with age-related cataract

Age-related cataract (ARC) is a leading cause of vision loss whose underlying mechanisms remain incompletely understood. Emerging evidence suggests the gut microbiota can influence ocular health via systemic metabolic and inflammatory pathways, yet the gut–eye connection in cataract has not been ...

2025-09-03 | MTBLS12932 | MetaboLights
ProteomicsComparative shotgun proteomics of aqueous humor for cataract, glaucoma and pseudoexfoliation eye disorders.
The aim of this work was to characterize proteome of aqueous humor from subjects with various eye conditions such as cataract, glaucoma and pseudoexfoliation syndrome by high-resolution chromate-mass-spectrometry. Twenty nine human aqueous humor samples were processed by shotgun proteomics. Data was...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080838 | MassIVE
TranscriptomicsTranscriptional profiling by array of human cataract samples to study the involvement of Type 1 interferon signalling in myotonic dystrophy types I and II
Comparison of myotonic dystrophy cataract samples with control non-myotonic dystrophy cataract samples
ORGANISM(S): Homo sapiens 
2011-10-31 | E-MEXP-3365 | biostudies-arrayexpress
ProteomicsSH2B1 Promotes Apoptosis in Diabetic Cataract via p38 MAPK Pathway
Diabetic patients face an increased risk of developing cataracts, with unclear mechanisms. Our study illuminates these mechanisms by identifying differentially expressed proteins in the lens anterior capsule of diabetic cataract (DC) and age-related cataract patients using quantitative proteomics. W...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059243 | Pride
Ophthalmology  protein interaction network  high-fat diet  diabetic cataract  cell culture Proteomics Oxidative stress  high-glucose environment  autophagy  epithelial–mesenchymal transition 
ProteomicsComparative shotgun proteomics of aqueous humor for cataract, glaucoma and pseudoexfoliation eye disorders.
The aim of this work was to characterize proteome of aqueous humor from subjects with various eye conditions such as cataract, glaucoma and pseudoexfoliation syndrome by high-resolution chromate-mass-spectrometry. Twenty nine human aqueous humor samples were processed by shotgun proteomics. Data was...
ORGANISM(S): Homo sapiens (Human) 
2016-05-23 | PXD002623 | Pride
Glaucoma Pseudoexfoliation syndrome Mass spectrometry Aqueous humor Eye disease Cataract Proteomics 
ProteomicsComparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and senile cataract eyes
Comparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and senile cataract eyes
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD004928 | Pride
Proteomics Glaucoma Cataract 
TranscriptomicsMutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma
This SuperSeries is composed of the following subset Series: GSE25774: Genome-wide analysis of Tdrd7 knockdown in lens epithelial-derived cell line 21EM15 GSE25775: Genome-wide analysis of 4-day old (P4) Tdrd7 null mouse lens GSE25776: Genome-wide analysis of 1 month old (P30) Tdrd7 null mouse lens ...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25812 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Tdrd7 knockdown in lens epithelial-derived cell line 21EM15
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25774 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of 4-day old (P4) Tdrd7 null mouse lens
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25775 | biostudies-arrayexpress
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