Sort   by:  
 Page size 
TranscriptomicsExpression profiles of (40,XX) and (39,XO) females
Gobal expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice with the aim of identifying which genes are expressed from both X chromosomes as well as those genes deregulated in X chromosome monosomy. Keywords: Expression profiling by array For ea...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-13520 | biostudies-arrayexpress
TranscriptomicsThe Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have been identified on MSYq, but because they are present in more than 40 copies...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29198 | biostudies-arrayexpress
TranscriptomicsThe Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis part 2
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have been identified on MSYq, but because they are present in more than 40 copies...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29200 | biostudies-arrayexpress
TranscriptomicsDeficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation
The gene Sly is present in multiple copies on the mouse Y chromosome and encodes a protein that is required for the epigenetic regulation of postmeiotic sex chromosome expression. The X chromosome carries two multicopy genes related to Sly: Slx and Slxl1. Here we investigate the role of Slx/Slxl1 us...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29197 | biostudies-arrayexpress
TranscriptomicsA genetic basis for a postmeiotic X vs. Y chromosome intragenomic conflict in the mouse
The Y-encoded multicopy gene Sly has been shown to repress X and Y genes in spermatids, among which are its X-linked homologs Slx and Slxl1, via modulation of post-meiotic sex chromain (PMSC). In this experiment, we compared expression in spermatids from mice that are deficient for Sly (shSLY), for ...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-39109 | biostudies-arrayexpress
TranscriptomicsTranscriptional consequences of Zfy1 and Zfy2 expression in GV oocytes
Sex-reversed ‘XYSry-’ female mice that lack Sry due to the 11 kb deletion Srydl1Rlb have very limited fertility, partly due to the effects of posessing only a single X chromosome. However, the fertility deficit is even worse in sex-reversed XY females than in XO females, implicating Y-linked genes i...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-52218 | biostudies-arrayexpress
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Not available
S-EPMC10208981 | biostudies-literature
Sort   by:  
 Page size