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TranscriptomicsTranscription profiling of human lymphoblast cells from a Freidriechs Ataxia patient incubated with pyrrole-imidazole polyamides targeted to the GAA triplet repeat in the intron 1 reveals polyamides alleviate transcription inhibition associated with long repeat srepeats in Friedreicha??s ataxia
Lymphoblast cells from a patient with Freidriech's Ataxia were incubated with pyrrole-imidazole polyamides targeted to the GAA triplet repeat in the intron 1. The polyamides were shown in cell culture to increase levels of endogenous frataxin mRNA. A normal sibling derived lymphoblast cell line wa...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5040 | biostudies-arrayexpress
UnknownSenolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
Not available
S-EPMC10006434 | biostudies-literature
TranscriptomicsTranscriptomic responses of juvenile Pacific whiteleg shrimp, Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia
Here we used microarrays to characterize changes in global gene expression in the hepatopancreas of Pacific white shrimp, Litopenaeus vannamei, exposed to short term (4 h) hypoxia (H) or hypercapnic hypoxia (HH) or long term (24 h) H or HH, compared to animals in air-saturated water (normoxia). Th...
ORGANISM(S): Litopenaeus vannamei 
2012-04-29 | E-GEOD-29029 | biostudies-arrayexpress
UnknownAn Examination of Follow-up Services Received by Vulnerable Burn Populations: A Burn Model System National Database Study.
Not available
S-EPMC9306190 | biostudies-literature
TranscriptomicsA Gene Expression Phenotype In Lymphocytes From Friedreich’s Ataxia Patients
Gene expression studies in peripheral tissues from patients with neurodegenerative disorders can provide insights into disease pathogenesis, and identify potential biomarkers, an important goal of translational research in neurodegeneration. Friedreich’s Ataxia (FRDA) is a chronic neurodegenerative ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30933 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of a 6h treatment with 2% isoflurane in the anterior cingulate cortex of the 24h old neonatal piglet brain
Exposure of the developing brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. In a range of animal species early developmental exposure to general anaesthesia without surgery, induces an increase in brain cell death, reductions in neuro and sy...
ORGANISM(S): Sus scrofa 
2016-10-04 | E-MTAB-5129 | biostudies-arrayexpress
UnknownImplementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.
Not available
S-EPMC7430215 | biostudies-literature
UnknownA multitiered analysis platform for genome sequencing: Design and initial findings of the Australian Genomics Cardiovascular Disorders Flagship.
Not available
S-EPMC11613726 | biostudies-literature
UnknownModern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005).
Not available
S-EPMC2866072 | biostudies-literature
UnknownUmbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants.
Not available
S-EPMC8084979 | biostudies-literature
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