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ProteomicsUveal melanoma-derived extracellar vesicles displayed transforming potential and carried portein cargo involved in metastatic niche preparation
Extracellular Vesicles (EVs) are oval membrane-enclosed structures with highlyheterogeneous content. EVs are known to play important roles in intercellular communication by transporting their contents between cells whereby they alter the properties of both donor and recipient cells.Uveal melanoma (U...
ORGANISM(S): Homo sapiens (Human) 
2025-06-19 | PXD019547 | Pride
Liver metastasis Mass spectrometry Extracellular vesicles Uveal melanoma 
ProteomicsCo-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
Uveal melanoma (UM) is the most common intraocular tumor in adults, and its pathogenesis is only partly understood. UM can develop de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbour UM-initiating mutations, most commonly in GNAQ ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD047179 | Pride
Uveal melanoma Proteomics Primary cell culture Human donor eyes 
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