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ProteomicsBreast cancer-derived extracellular vesicles modulate the cytoplasmic metabolism and cytoskeletal mechanics of blood-brain barrier endothelial cells
Normal cerebral vasculature is characterized by high selectivity, low permeability and low transcytosis rates, ensuring proper brain physiology. Our group has demonstrated that extracellular vesicles isolated from brainseeking MDA-MB-231 cells (Br-EVs) breach the intact BBB in vivo and significantly...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053436 | Pride
Breast cancer Exosomes Microvesicles Extracellular vesicles Pre-metastatic niche Brain metastasis Blood-brain barrier 
TranscriptomicsInterference with ethylene perception at receptor level sheds light on auxin and transcriptional circuits associated with climacteric ripening of apple fruit (Malus x domestica Borkh.)
Apple (Malus x domestica Borkh.) is a model fruit species to study the metabolic changes occurring at the onset of ripening as well the physiological mechanism governed by the hormone ethylene. In this survey, to dissect the climacteric interplay in apple, a multidisciplinary approach was employed. ...
ORGANISM(S): Malus domestica 
2016-08-23 | E-GEOD-78745 | biostudies-arrayexpress
TranscriptomicsIntegrative approach combining transcriptomic assay with physical and metabolite analysis reveal novel clues about the regulatory mechanism governing the climacteric ripening physiology in apple (Malus x domestica Borkh.) [WGAA]
Apple (Malus x domestica Borkh.) is a model fruit species to study the metabolic changes occurring at the onset of ripening as well the physiological mechanism governed by the hormone ethylene. In this survey, to dissect the climacteric interplay in apple, a multidisciplinary approach was employed. ...
ORGANISM(S): Malus domestica 
2016-08-23 | E-GEOD-78744 | biostudies-arrayexpress
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