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ProteomicsAgonist-induced phosphorylation of orthologues of the orphan receptor GPR35 as an activation biomarker
Mass spectrometry, mutagenesis and labelling with [32P] orthophosphate identified that each of the five hydroxy-amino acids in the intracellular C-terminal tail of human GPR35a became phosphorylated in response to agonist occupancy of the receptor and that, apart from Ser294, each of these contribut...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030548 | Pride
Gpcr 
ProteomicsGRK2/3-regulated, but not constitutive, phosphorylation of the G protein-coupled receptor GPR84 controls arrestin interactions and subsequent function
Although the GPR84 activators 2-HTP and 6-OAU promoted phosphorylation of human GPR84 and its interactions with arrestin-3, PSB-16671 and DL-175 did not. Replacement of all 21 serine and threonine residues within the third intracellular loop, but not the 2 serines in the C-terminal tail, eliminated ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031252 | Pride
Gpcr Phosphorylation 
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