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TranscriptomicsTranscription profiling of human A549 pneumocyte cells infected with wild type and type III secretion system mutants of Pseudomonas aeruginosa
The bacterial type III secretion system (TTSS) is dedicated to directly effect host cell pathways by pathogens. In order to identify the key host responses of the various parts of the TTSS, we utilized expression profiling of a lung pneumocytes cell line, A549, exposed to various isogenic mutant str...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1469 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
ProteomicsAllogeneic antibodies specifically target AML antigen NuSAP1 after bone marrow transplantation
Identifying the targets of immune response after allogeneic hematopoietic cell transplantation (HCT) promises to provide relevant immune therapy candidate proteins. We used protein microarrays to serologically identify Nucleolar and Spindle Associated Protein 1 (NuSAP1) and Chromatin Assembly Factor...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-15255 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression Profiles in CD34+ Myelodysplastic Syndrome Marrow cells to Disease Subtype and Progression
Microarray analysis with 40,000 cDNA gene chip arrays determined differential gene expression profiles (GEPs) in CD34+ marrow cells from myelodysplastic syndrome (MDS) patients compared to normal individuals. Using focused bioinformatics analyses, we found 1175 genes significantly differentially ex...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18366 | biostudies-arrayexpress
GenomicsSequencing and analysis of a South Asian-Indian personal genome
India with over 1.3 billion people is estimated to carry three times more genetic diversity compared to Europe. Next-generation sequencing technologies have facilitated the understanding of diversity by enabling whole genome sequencing at greater speed and lower cost. While multiple genomes from p...
EGAS00001000328 | EGA
ProteomicsIdentifying Compartment-specific Alloimmune Targets After Renal Transplantation by integrated genomics
Microarray technology has evolved as a powerful tool over the last decade, to identify biomarkers and study the mechanisms of diseases. We propose a novel application of integrated genomics by combining transcriptional levels with serological antibody profiling after kidney transplantation, with the...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10452 | biostudies-arrayexpress
TranscriptomicsLocal regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts
The biopsy samples obtained at implantation segregated in 2 distinct groups according to donor origin, with a cluster of 319 unique identified genes higher expressed in DD compared to LD kidneys, and 329 genes lower expressed (false discovery rate <5%). Using pathway analysis software a significant ...
ORGANISM(S): Homo sapiens 
2008-04-16 | E-GEOD-11166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P5 cerebellum to investigate conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of neuroblastoma
Identification of common mechanisms underlying organ development and primary tumor formation should yield new insights into tumor biology and facilitate the generation of relevant cancer models. We have developed a novel method to project the gene expression profiles of medulloblastomas (MBs)—human ...
ORGANISM(S): Mus musculus 
2009-01-30 | E-GEOD-14514 | biostudies-arrayexpress
GenomicsMus musculus
Role of FoxO3 in adult neural stem cell maintenance in mice
PRJNA117981 | ENA
TranscriptomicsPBC tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice.
41K whole genome oligo-microarrays (Agilent Technologies) were used to characterize age-dependent changes in gene expression in peripheral blood cells (PBC) obtained from up to 8 individual NOD mice at 6 different time points (10 days (n=8), and 4 weeks (n=3), 8 weeks (n=7), 12 weeks (n=8), 16 weeks...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-21897 | biostudies-arrayexpress
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