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MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Murine assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9100 | MetaboLights
MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Human assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9087 | MetaboLights
MetabolomicsButyric acid derived from porcine-derived antioxidant probiotic PGM326 enhances intestinal cell differentiation by promoting oxidative phosphorylation

This study not only identified an efficient host-homologous antioxidant probiotic, PGM326, but also systematically elucidated its mechanism of exerting antioxidant function by synthesizing BA to promote OXPHOS in intestinal epithelial cells, thereby enhancing cell differentiation. This provides a...

2026-02-01 | MTBLS13818 | MetaboLights
TranscriptomicsMetabolite stress response to butyric acid in Clostridium acetobutylicum ATCC 824
Clostridium acetobutylicum is a Gram positive, endospore forming firmicute that has been known as the model organims for ABE (acetone-butanol-ethanol) fermentation. With its ability to consume a wide variety of substrates, C. acetobutylicum carries out a biphasic ABE fermentation, which consists of ...
ORGANISM(S): Clostridium acetobutylicum ATCC 824 
2013-08-20 | E-GEOD-48039 | biostudies-arrayexpress
TranscriptomicsNext Generation Metatranscriptome Sequencing of an Anaerobic Hexadecane-Degrading Microbial Consortia
Purpose: Identification of transcriptionally active genes in the unculturable community constituent, Smithella, during hexadecane degradation; Differential gene expression analysis of hexadecane-relevant genes acoss three different conditions; Extension of metatranscriptomic datasets to other commun...
ORGANISM(S): mixed culture KAZ_0815 
2013-10-29 | E-GEOD-49830 | biostudies-arrayexpress
TranscriptomicsThe tinkerbell (tink) mutation identifies the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a novel regulator of organ size in Arabidopsis.
Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK ph...
ORGANISM(S): Arabidopsis thaliana 
2015-07-30 | E-GEOD-66419 | biostudies-arrayexpress
ProteomicsProteomic analysis of butyric acid inhibition of the growth of E. coli
To further characterize the mechanism of action of the organic acids, ultra-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to analyze E. coli samples co-cultured with butyric acid using iTRAQ quantitative proteomics technology.
ORGANISM(S): Escherichia Coli 
2024-11-11 | PXD057728 |
MetabolomicsMetabolomic analysis on Microcystis aeruginosa cells under various amino acid supplementation conditions
Threonine, an essential amino acid for translation, exhibits toxicity towards slow-growing cyanobacteria. This prompted us to perform transcriptomic and proteomic analyses using Microcystis aeruginosa cells treated with threonine, revealing a noteworthy upregulation of thrC, annotated as pyridoxal 5...
2025-04-02 | MTBLS11852 | MetaboLights
TranscriptomicsExpression data from Arabidopsis wild type and ibr1 ibr3 ibr10 triple mutant seedlings root tip segments treated with indole-3-butyric acid (IBA)
The root cap-specific conversion of the auxin precursor indole-3-butyric acid (IBA) into the main auxin indole-3-acetic acid (IAA) generates a local auxin source which subsequently modulates both the periodicity and intensity of auxin response oscillations in the root tip of Arabidopsis, and consequ...
ORGANISM(S): Arabidopsis thaliana 
2015-05-12 | E-GEOD-59426 | biostudies-arrayexpress
GenomicsNovel intestinal markers in newly diagnosed AML patients: Enterococcus faecium and butyric acid
Enterococci, butyric acid have excellent diagnostic efficacy in acute myeloid leukemia.
PRJEB79919 | ENA
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