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GenomicsA study of the effect of OxLDL on C/EBP beta binding in human macrophages using chromatin immunoprecipitation for C/EBP beta with high throughput sequencing (ChIP-seq)
We report the C/EBP beta transcription factor binding landscape in human macrophages and oxLDL-induced foam cells ChIP-seq for C/EBP beta binding was performed in human macrophages and oxLDL induced-foam cells with quadruple biological replicates
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-66192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fibroblast cells transfected with zinc-inducible C/EBP expression vectors identifies Per2 as a gene implicated in myeloid leukemia
The zinc-inducible C/EBP expression vectors pMTa, pMTb, pMTd and pMTe were constructed by cloning the human C/EBPa, C/EBPb, C/EBPd and C/EBPe cDNAs, respectively, into the pMTCB6+ vector. NIH 3T3 cells were transfected with zinc-inducible C/EBP vectors as well as control empty vector using the GeneP...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2188 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and A-C/EBP transgenic mouse embryonic fibroblasts during adipogenesis to identify C/ebp alpha target genes
This experiment was designed to identify C/ebp alpha target genes during the process of adipogenesis by means of comparison of differentiating (wild-type) cells to a perturbation model (transgenic cells). For this, gene expression profiling during adipogenesis of mouse embryonic fibroblasts (MEFs) ...
ORGANISM(S): Mus musculus 
2009-07-02 | E-MARS-11 | biostudies-arrayexpress
TranscriptomicsC/EBP? and PPAR?-specific transcriptional programs in mature adipocytes in vivo
We took a systematic approach to determine the transcriptional programs that are specifically regulated by C/EBP? in mature white adipocytes of mice on chow diet or high fat diet. The hypothesis tested in the present study was that C/EBP?, as a lipogenic transcription factor, has unique direct targe...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-62937 | biostudies-arrayexpress
TranscriptomicsCCAAT/Enhancer Binding Proteins (C/EBP)-M-NM-1 and -M-NM-2 are Essential for Ovulation, Luteinization and the Expression of Key Target Genes
Luteinizing hormone (LH) activation of the EGF receptor/RAS/ERK1/2 pathway is essential for ovulation and luteinization because granulosa cell depletion of Erk1/2 (Erk1/2gc-/- mice) renders mice completely infertile. Because of their potential as mediators of ERK1/2-dependent granulosa cell differe...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-23084 | biostudies-arrayexpress
GenomicsLKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer [C/EBP Bulk RNA-seq]
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer [C/EBP Bulk RNA-seq]
PRJNA744200 | ENA
TranscriptomicsSox4 is a key oncogenic target in C/EBP? mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBP? is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2013-03-23 | E-GEOD-45430 | biostudies-arrayexpress
TranscriptomicsC/EBP? poises B cells for rapid reprogramming into iPS cells [RNA-Seq]
C/EBP? induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBP? accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52396 | biostudies-arrayexpress
TranscriptomicsLenalidomide-mediated enhanced translation of C/EBP?-p30 protein upregulates expression of the anti-leukemic microRNA-181a in acute myeloid leukemia - microRNA Data
Recently, we showed that increased miR-181a expression was associated with improved outcomes in cytogenetically normal acute myeloid leukemia (CN-AML). Interestingly, miR-181a expression was increased in CN-AML patients harboring CEBPA mutations, which are usually biallelic and associate with better...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-MTAB-1320 | biostudies-arrayexpress
GenomicsC/EBP⍺ Aggravated Ferroptosis and Apoptosis in Renal Tubular Epithelial Cell
C/EBP⍺ Aggravated Ferroptosis and Apoptosis in Renal Tubular Epithelial Cell
PRJNA1014769 | ENA
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