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TranscriptomicsTranscription profiling of skeletal and cardiac muscles in dysferlin-deficient SJL/J mice and wild type mice to understand the protective mechanisms against dysferlin deficiency in cardiac muscles.
Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2507 | biostudies-arrayexpress
MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
TranscriptomicsV(D)J TCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J TCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14899 | biostudies-arrayexpress
TranscriptomicsV(D)J BCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J BCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of individual bovine nuclear transfer blastocysts
Individual zona free in vitro grown bovine day 7 blastocysts were compared to stage and quality matched nuclear transfer derived blastocysts (fibroblast donor cells).
ORGANISM(S): Bos taurus 
2006-02-14 | E-MEXP-556 | biostudies-arrayexpress
TranscriptomicsThe effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis; insights for early bactericidal activity
Background: Pyrazinamide (PZA) plays an essential part in the shortened 6-month tuberculosis (TB) treatment course due to its activity against slow-growing, semi-dormant organisms. We tested the paradigm that PZA preferentially targets slow growing cells of Mycobacterium tuberculosis that remain aft...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-03-25 | E-MTAB-4093 | biostudies-arrayexpress
TranscriptomicsExpression profiling of exposure to phorbol myristate acetate - PMA and FOXK2 depletion with siRNA
Expression profiling was done of exposure to phorbol myristate acetate -PMA and FOXK2 depletion by siRNA transfection. This was done on the human osteosarcoma U2OS cell line which stably expresses FOXK2. PMA is an inducer of AP1 activity.
ORGANISM(S): Homo sapiens 
2011-11-03 | E-MEXP-3107 | biostudies-arrayexpress
TranscriptomicsExpression profiling of FOXK2 depletion by siRNA
Expression profiling was done of FOXK2 depletion by siRNA transfection. This was done on the human osteosarcoma U2OS cell line (which stably expresses FOXK2).
ORGANISM(S): Homo sapiens 
2011-11-03 | E-MEXP-3106 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis efpA CRISPRi knock-down transcriptional profile - induced efpA knock-down strain vs non-induced condition
In Mycobacterium tuberculosis, the efflux pump, EfpA, plays an essential but uncharacterised role in its physiology and antibiotic tolerance. In this study, an ATc-inducible CRISPR interference (CRISPRi) system was introduced into M. tuberculosis to knock-down the expression of efpA and determine an...
ORGANISM(S): Mycobacterium tuberculosis 
2024-06-19 | E-MTAB-13755 | biostudies-arrayexpress
TranscriptomicsThree-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [Hi-C]
A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform Hi-C chromosome conformation to investigate how the t...
ORGANISM(S): Homo sapiens 
2016-04-04 | E-GEOD-73782 | biostudies-arrayexpress
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