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Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
TranscriptomicsGene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs
Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for leukemia stem cells (LSCs), we showed that BCR-ABL down-regulates the B lymphoid kinase (Blk) gene in leukemia stem cells in CML mice and that Blk functions as a tumor suppressor in LSCs and suppresses LSC function. Inhibiti...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-36096 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Alox5-/-LSCs
We previously demonstrated that Alox5 deficiency impairs the function of LSCs and prevents the initiation of BCR-ABL-induced CML. To identify the pathways in which Alox5 gene regulates function of LSCs, we performed a comparative DNA microarray analysis using total RNA isolated from non-BCR-ABL-expr...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29347 | biostudies-arrayexpress
TranscriptomicsRNA microarray of human cervical cancer cell line HeLa treated with imatinib, mitoxantrone or mitoxantrone+imatinib combination against untreated controls
Critical DNA repair pathways become deranged during cancer development. This vulnerability may be exploited with DNA-targeting chemotherapy. Topoisomerase II inhibitors induce double-strand breaks which are detrimental to the cell, if not repaired. This repair process requires high-fidelity function...
ORGANISM(S): Homo sapiens 
2021-09-22 | E-MTAB-9475 | biostudies-arrayexpress
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo sapiens (Human) 
2015-08-06 | PXD001737 | Pride
Molecular chaperone Q-exactive C-abl 18o labeling Aha1 Co-chaperone Heat shock protein 90 Quantative proteomics 
TranscriptomicsC-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5´ region of Cdk6
The transcription factor c-JUN and its upstream kinase JNK1 have been implicated in BCR-ABL induced leukemogenesis. JNK1 has been shown to regulate BCL2 expression thereby altering leukemogenesis, but the impact of c-JUN remained unclear. In this study we show that JNK1 and c-JUN promote leukemogene...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-27028 | biostudies-arrayexpress
GenomicsGene transcription in wild-type (WT) and c-abl/arg knockout MEFs
Gene transcription in wild-type (WT) and c-abl/arg knockout MEFs
PRJNA646708 | ENA
TranscriptomicsNS1-mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections; insights into 1918 H1N1 pandemic
NS1 proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations. In the current study, we addressed the consequences of NS1-mediated alteration of c-Abl on acute lung injury and...
ORGANISM(S): Mus musculus 
2014-11-03 | E-GEOD-62169 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR/ABL-expressing LSCs and BCR/ABL-expressing Hif1a-/-LSCs
Using a mouse model of chronic myelogenous leukemia (CML), here we report that HIF1M-NM-1 plays a crucial role in survival maintenance of leukemia stem cells (LSCs). Deletion of HIF1M-NM-1 impairs the propagation of CML through impairing cell cycle progression and inducing apoptosis of LSCs. Deletio...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35111 | biostudies-arrayexpress
GenomicsInfection and herbicide exposure implicate c-Abl kinase in α-synuclein serine 129 phosphorylation
Infection and herbicide exposure implicate c-Abl kinase in α-synuclein serine 129 phosphorylation
PRJNA1213773 | ENA
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