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Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
TranscriptomicsOverexpression of c-Jun in mouse Schwann cells of uninjured nerves
Two mouse lines, OE/+ and OE/OE were generated expressing graded elevation (6 fold and 28 fold, respectively) of c-Jun protein selectively in Schwann cells. The effects of this on global gene expression and cellular structure in uninjured nerves was analysed during development and in the adult. Chan...
ORGANISM(S): Mus musculus 
2017-10-16 | E-MTAB-6138 | biostudies-arrayexpress
TranscriptomicsCHIP Analysis - c-Jun/ATF2
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1810 | biostudies-arrayexpress
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
TranscriptomicsInterplay between c-Jun and TAp73M-NM-1/M-NM-2 contributes to the apoptosis-survival balance
The p53-family member p73 functions in various cellular signaling pathways and can have tumor suppressor properties. Several isoforms of p73 exist that differ considerably in their function. Whereas the functions of the N-terminal isoforms (TA and M-NM-^TNp73) and their opposing pro- and anti-apopto...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-15780 | biostudies-arrayexpress
Transcriptomicsc-Jun impedes somatic cell reprogramming by activating mesenchymal core regulators and suppressing pluripotent ones
The somatic cell fate can be converted to tumor or pluripotent ones by ectopic expression of transcription factors in vitro and in vivo. Many oncogenic transcription factors are known to mediate both fates as they share similar proliferative and metabolic properties. Paradoxically, we found c-Jun as...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-50776 | biostudies-arrayexpress
no omics definedTranscription profiling by array of mouse liver from TCPOBOP treated wild type and c-jun conditional knockout animals
c-jun conditional knockout mice (c-jun?li) and relative controls (c-junf/f) were treated with TCPOBOP (3mg/Kg of body weight) and were sacrificed at 0, 1, 3 and 6 hours later. Gene expression analysis was performed on total RNA pools extracted from fresh frozen livers of 3 animals per group. For e...
ORGANISM(S): Mus musculus 
2011-03-04 | E-TABM-935 | biostudies-arrayexpress
GenomicsCUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
Other than in the development of the brain, SOX2 is essential for the long-term self-renewal of neural stem cells (NSCs). The mechanisms of how SOX2 maintains the stemness of NSCs is not yet understood. We have identified Fos as a downstream target of SOX2, and therefore used CUT&RUN to investigate ...
ORGANISM(S): Mus musculus 
2021-04-01 | E-MTAB-9897 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
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