Sort   by:  
 Page size 
OtherLysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.
Data from ProteomeXchange: PXD ID: PXD001114. Experiment: LysargiNase, silac, file: LR_Ulilysin_PMA_A1_121126.mzml. Published as part of . From the Abstract: {{i}} To improve proteome coverage and protein C-terminal identification, we characterized the Methanosarcina acetivorans thermophilic protei...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310005457 | GPMDB
Resource Reanalysis 
TranscriptomicsThe C-Terminal Domain of RNA Polymerase II is Modified by Site-Specific Methylation
The Carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) in mammals undergoes extensive post-translational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the transcriptional co-...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-27315 | biostudies-arrayexpress
ProteomicsTwo DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase processively produces H3K79me2/me3 from me0 through histone H2B mono-ubiquitin interaction. The early-branched kinetoplastid Trypanosoma brucei harbors the essential H3K76 di-methyltransferase DOT1A and the non-essent...
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-09 | MSV000090680 | MassIVE
ProteomicsCharacterization of the C-terminal post-translational modification pattern of the catalytic C subunit of protein phosphatase 2A by mass spectrometry.
Protein phosphatase 2A (PP2A) is an important regulator of cellular signal transduction pathways. The carboxy-terminal tail of the PP2A catalytic C subunit is thought to be post-translationally modified at three critical sites. Carboxy-terminal methyl-esterification at Leucine 309 is essential for t...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-28 | PXD014879 | Pride
Tyrosine phosphorylation C-terminal protein methylation Protein phosphatase 2a Ptyr307- specific antibodies 
ProteomicsLysine Methylation Promotes VEGFR-2 Activation and Angiogenesis
We have used a chimeric VEGFR-2 in which the extracellular domain of mouse VEGFR-2 was replaced with the extracellular domain of human CSF-1 receptor. VEGFR-2 was immunoprecipitated with anti-VEGFR-2 antibody from PAE cells ectopically expressing VEGFR-2. The immunoprecipitated proteins were eluted...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-22 | PXD000520 | Pride
In-gel digestion Lc-ms/ms 
GenomicsGenome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells
We apply cellular reprogramming to an induced pluripotent cell state to human cell lines and primary samples exhibiting Chronic Myoloid Leukemia (CML). Addtionally, we generated an inducible CML BCR-ABL transgenic mouse model. Biological replicates (duplicates) were available for all samples. DNA me...
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-50456 | biostudies-arrayexpress
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
ProteomicsKv7.2 LC-MSMS - Updating in vivo and in vitro phosphorylation and methylation sites of voltage-gated Kv7
Voltage-gated Kv7.2 potassium channels regulate neuronal excitability. The gating of Kv7 channels is regulated by various mediators and neurotransmitters acting via G protein-coupled receptors; the underlying signalling cascades involve phosphatidylinositol-4,5-bisphosphate (PIP2), Ca2+/Calmodulin a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2017-08-25 | PXD005567 | Pride
Methylation Kv7.2 Phosphorylation Kcnq2 
UnknownThe C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation.
Not available
S-EPMC7307107 | biostudies-literature
ProteomicsTWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in Glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor among adults, which is characterized by high invasion, migration and proliferation abilities. One important process that contributes to the invasiveness of GBM is the epithelial to mesenchymal transition (EMT). EMT...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD029361 | Pride
Glioblastoma Methylation Setd6 Methyltransferase 
Sort   by:  
 Page size