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Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-22 | MTBLS15760 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-01 | MTBLS15516 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-08-30 | MTBLS15501 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-14 | MTBLS15663 | MetaboLights
Metabolomics13(S)-HODE Generated by Rhizopus microsporus var. rhizopodiformis Aggravates MASLD via the Elane-PAR2-SREBP-1c Axis
Abstract Objective:Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) poses a major public health challenge. Increasing data suggest a role of gut fungi in liver disease, yet their diversity and biological function in MASLD are still poorly understood. Methods:Internal transcribed spac...
2026-09-14 | MTBLS15643 | MetaboLights
GenomicsComplement Protease C1s Drives Immunosuppression in Mesenchymal Glioblastoma by Rewiring Microglia Metabolism
Complement Protease C1s Drives Immunosuppression in Mesenchymal Glioblastoma by Rewiring Microglia Metabolism
PRJNA1387235 | ENA
ProteomicsProteomic analysis of surface proteins from C1s siRNA-treated UT-SCC-59A squamous cell carcinoma cells
To investigate the effect of C1s on cell surface proteins cSCC cell cultures were transfected with 120 nM control or C1s siRNAs and after 3 days incubation, the cells were biotinylated collected by streptavidin beads and subsequently analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD065511 | Pride
Squamous cell cancer Complement C1s Biotinylation 
TranscriptomicsComplement Protease C1s Drives Immunosuppression in Mesenchymal Glioblastoma by Rewiring Microglia Metabolism
The mesenchymal (MES) subtype of glioblastoma (GBM) exhibits a highly immunosuppressive tumor microenvironment (TME) and poor prognosis, but the underlying mechanism remains largely unclear. Herein, we demonstrate that the MES-GBM cells-derived complement protease C1s plays a crucial role in suppres...
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE313917 | GEO
GenomicsRNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of C1s.
RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of C1s.
PRJNA495364 | ENA
UnknownQuantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s.
Not available
S-EPMC9904206 | biostudies-literature
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