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ProteomicsIdentification of C2CD4A and C2CD4B binding partners in MIN6 cells
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Whilst previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B. Here, we show that systemic...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD021597 | Pride
C2cd4a  c2cd4b  interaction proteomics 
GenomicsIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion [RNA-Seq]
Identification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion [RNA-Seq]
PRJNA546496 | ENA
TranscriptomicsIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion [RNA-Seq]
To investigate the function of C2CD4A, we analyzed RNA profiles in MIN6 cells expressing C2cd4a-GFP or control-GFP.
ORGANISM(S): Mus musculus 
2019-07-31 | GSE132200 | GEO
UnknownIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion.
Not available
S-EPMC6778232 | biostudies-literature
UnknownA Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.
Not available
S-EPMC5985342 | biostudies-literature
GenomicsIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion
Identification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion
PRJNA546494 | ENA
GenomicsIdentification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion [ChIP-Seq]
Identification of C2CD4A as a human diabetes susceptibility gene with a role in β-cell insulin secretion [ChIP-Seq]
PRJNA545416 | ENA
TranscriptomicsSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Here have performed RNAseq on pancreatic islets from C2CD4B-null mice and their littermate controls.
ORGANISM(S): Mus musculus 
2020-09-16 | GSE152576 | GEO
UnknownSexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
Not available
S-EPMC7829492 | biostudies-literature
GenomicsMouse, Rat
A common type 2 diabetes risk variant potentiates activity of an evolutionarily conserved islet stretch enhancer and increases C2CD4A/B expression
PRJNA398550 | ENA
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