C3 inhibitor - OmicsDI

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Mass Spectrometry (35)
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Instrument Platform

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CHEBI ID

CHEBI:16695 (3)
CHEBI:16015 (3)
CHEBI:15603 (3)
CHEBI:17768 (2)
CHEBI:15859 (2)
CHEBI:17013 (2)
CHEBI:16680 (2)
CHEBI:17202 (2)
CHEBI:16349 (2)
CHEBI:15729 (2)
CHEBI:17361 (2)
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CHEBI:17203 (2)
CHEBI:15971 (2)
CHEBI:16857 (2)
CHEBI:17552 (2)
CHEBI:16027 (2)
CHEBI:16761 (2)
CHEBI:17345 (2)
CHEBI:30797 (2)
CHEBI:30915 (2)
CHEBI:16414 (2)
CHEBI:16643 (2)
CHEBI:17895 (2)

Metabolite Name

L-leucine (2)
L-glutamic acid (2)
L-cysteinylglycine (1)
Quercetin 3-O-glucoside 7-O-rhamnoside (1)
Kaempferol 3-O-glucoside 7-O-rhamnoside (1)
S-Adenosyl methionine (1)
4-[(2E)-3,7-dimethyl-5-oxoocta-2,6-dienyl]-3-methylideneoxolan-2-one (1)
Pyridoxamine-5'-phosphate (1)
4-hydroxy-4-[(E)-3-hydroxybut-1-enyl]-3,5,5-trimethylcyclohex-2-en-1-one (1)
(2E)-11-Hydroxy-2-dodecenoic acid (1)
N-epsilon,N-epsilon,N-epsilon-Trimethyllysine (1)
Alpha-aminopimelic acid (1)
N-Acetyl-L-ornithine (1)
Fenchyl alcohol (1)
Pyridoxol (1)
L-Methionine methylsulfonium (1)
N-(2-Hydroxyethyl)-beta-alanine (1)
Beta-Hydroxynorvaline (1)
3,4-Dimethylaniline (1)
Gamma-Amino-beta-hydroxybutyric acid (1)
(R)-2-Aminobutanoic acid (1)
2',3'-Cyclic Adenosine monophosphate (1)
Alpha-D-Talose (1)
L-homocysteine (1)
N(1)-acetylspermidine (1)
L-alpha-aminobutyric acid (1)
Dihydroorotic acid (1)
O-isovalerylcarnitine (1)
O-propanoylcarnitine (1)
(Nω-L-arginino)succinic acid (1)

First Public Date

2025 (5)
2014 (5)
2021 (4)
2023 (3)
2026 (2)
2022 (2)
2019 (2)
2015 (2)
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Classification

bacteria (1)

Study type

Transcription profiling by array (273)
RNA-seq of coding RNA (53)
Unknown experiment type (18)
ChIP-seq (18)
RNA-seq of coding RNA from single cells (15)
RNA-seq of total RNA (10)
Comparative genomic hybridization by array (7)
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ChIP-chip by array (4)
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Release Date

2025 (89)
2010 (77)
2014 (62)
2023 (62)
2013 (58)
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2015 (55)
2012 (48)
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2009 (44)
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2008 (40)
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2018 (33)
2019 (31)
2017 (23)
2005 (19)
2007 (18)
2006 (12)
2004 (4)
2003 (2)
2002 (2)
1999 (1)

Lab affiliation

Aarhus University Department of Biomedicine Høegh-Guldbergsgade 10 DK-8000 Aarhus C (1)
Boston University (1)
CAS Center for Excellence in Molecular Plant Science, Chinese Academic on Science (1)
Changchun University of Chinese Medicine (1)
College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, China (1)
College of Biology, Hunan University, China (1)
Department of Biochemistry and Molecular Biology, University of Salamanca (Salamanca, Spain). Instituto de Investigación Biomédica de Salamanca (IBSAL) (Salamanca, Spain). (1)
Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul 06355, Korea (1)
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. (1)
Department of Plant and Environmental Sciences, University of Copenhagen (1)
Drug Discovery Biology Theme Monash Institute of Pharmaceutical Sciences Monash University 399 Royal Parade (Mail address: 381 Royal Parade) Parkville VIC 3052 Australia (1)
Faculty of Biology, Technion - Israel Institute of Technology, Haifa 32000, Haifa, Israel (1)
Federal University of Rio de Janeiro (1)
Functional Proteomics Lab, Faculty of Biology, University of Freiburg, Germany (1)
German Center for Neurodegenerative Diseases (DZNE) Munich (1)
Graduate Institute of Biomedical Sciences, department of Cell and Molecular Biology, College of Medicine, and Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan. Liver Research Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 33302, Taiwan. (1)
Harvard Medical School, Brigham and Women's Hospital (1)
Institut Pasteur, Université Paris Cité, INSERM U1225, Pathogenesis of Vascular Infections unit, F-75015 Paris, France (1)
Korea Institute of Science and Technology (1)
MIT (1)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health & Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark (1)
Princess Margaret Cancer Centre, University Health Network, M5G 1L7, Toronto, Canada (1)
Professor of Cell Biology and Parasitology Division of Biological Chemistry and Drug Discovery School of Life Sciences University of Dundee DUNDEE DD1 5EH UK (1)
Professor of the Department of Cell Biology and Associate Dean for Graduate Biomedical Education (1)
Professor, Institutionen för odontologi (DENTMED), OF, Karolinska Institutet (1)
Proteomics Center Erasmus University Medical Center (1)
Proteomics, Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (1)
School of Natural Sciences,Faculty of Science and Engineering, Macquarie University (1)
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China (1)
Translational Gastroenterology,GIGA institute,University of Liège, Belgium Hepato-Gastroenterology and Digestive Oncology Dep., University hospital of Liège, BE (1)

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Gingival exudatome dynamics implicates inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis

Complement inhibition has been successfully used to treat periodontitis in animal models. However, proteome studies that investigated the role of complement C3 were missing. The objective of this study was to characterize local tissue exudate (“gingival crevicular fluid”; GCF) changes after administ...

ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

2018-08-17 | PXD009502 | Pride

C3 inhibitor Gcf Periodontitis Macaca fascicularis

Complement C3 deposition on nucleic acids is characteristic of immune complex initiated classical pathway overdrive in lupus erythematosus

Systemic lupus erythematosus is progressive, immune complex-mediated autoimmune disease targeting numerous organs. A central feature of the disease is the development of antibodies against nuclear components, including DNA. Antibodies against double-stranded DNA are so characteristic of this disease...

ORGANISM(S): Homo sapiens

2012-09-30 | E-GEOD-26768 | biostudies-arrayexpress

Genomic rearrangements in C3 glomerulopathies

Copy number variations and genomic rearrangements in the CFH-CFHRs region were assessed with a custom-designed high-density 8x15k oligonucleotide CGH arrays spanning the RCA gene cluster region in human chromosome 1q32 (median resolution of 110 bp) (AMADID 040193, Agilent Technologies, Santa Clara, ...

ORGANISM(S): Homo sapiens

2013-05-28 | E-GEOD-45585 | biostudies-arrayexpress

Inhibition of Androgen Receptor and β-catenin activity in prostate cancer

Androgen receptor (AR) is the major therapeutic target in aggressive prostate cancer. However, targeting AR alone can result in drug resistance and disease recurrence. Therefore, simultaneous targeting of multiple pathways could in principle be an effective new approach to treating prostate cancer. ...

ORGANISM(S): Homo sapiens

2014-01-23 | E-GEOD-49295 | biostudies-arrayexpress

Neutrophil Extracellular Trap-borne C3-Driven Endothelial Dysfunction in Klebsiella pneumoniae Liver Abscess

Klebsiella pneumoniae liver abscess (KPLA) is a severe bacterial infection complicated by intrahepatic thrombophlebitis and extrahepatic metastatic infections, leading to high mortality rates. This study investigates the role of neutrophil extracellular traps (NETs) in endothelial injury and disease...

ORGANISM(S): Mus musculus

2025-03-21 | GSE288691 | GEO

Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.

Not available

S-EPMC8946527 | biostudies-literature

Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut

Host-derived factors are sucked into midgut of mosquitoes during natural malaria transmission, but their influence on malaria transmission is largely unknown. We reported that mouse complement C3 taken into mosquitoes significantly promoted malaria transmission either in laboratory or in field. This...

ORGANISM(S): Anopheles stephensi

2024-08-01 | GSE271070 | GEO

Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor.

Not available

S-EPMC7991574 | biostudies-literature

Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut

PRJNA1129548 | ENA

Neutrophil Extracellular Trap-borne C3-Driven Endothelial Dysfunction in Klebsiella pneumoniae Liver Abscess

PRJNA1219081 | ENA

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