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MetabolomicsNatural photosynthetic system for restoring homeostasis of animal organelle interaction network

Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Current treatments usually focus on individual organelles while ignoring the role of organelle interactions in cell damage caused by cascade reactions. The...

2026-01-20 | MTBLS13730 | MetaboLights
ProteomicsAltered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD042994 | Pride
Membrane contact sites (mcs) Glycosphingolipids (gsls) Proteomics 
ProteomicsDisruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass
STIM1 is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is indispensable during development, its biological and metabolic functions in mature muscle ...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-30 | PXD030674 | JPOST Repository
GenomicsMitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [mRNA]
Mitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [mRNA]
PRJNA773762 | ENA
ModelsAstaburuaga2019 - ODE model of lysosomal ion homeostasis (LIH) including calcium pathways
To investigate the putative differential effect of chloride transport on lysosomal ion homeostasis,we generated an ODE mathematical model for this system. Our mathematical model builds upon a previously published model for lysosomal homeostasis (Grabe et al. 2001 J. Gen. Physiol, Ishida et al. 2013 ...
2019-10-22 | MODEL1910220001 | BioModels
GenomicsMitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [Ribo-seq]
Mitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [Ribo-seq]
PRJNA773765 | ENA
TranscriptomicsSphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis
Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphoryled by the actions of two S1P-specific phosphatases, sphingosine 1-phosphate phosphatase 1 and 2. To identify the physiologic functions of S1P p...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-40368 | biostudies-arrayexpress
GenomicsDifferentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+ influx
Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+ influx
PRJNA817570 | ENA
TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
GenomicsMitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
Mitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
PRJNA1429310 | ENA
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