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ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
ProteomicsHost-defence peptides caerin 1.1 and 1.9 stimulate TNF-alpha-dependent apoptosis in human cervical cancer HeLa cells
TNFα pathway has been recognised as one of the most important signalling pathways characterising molecules with anti-cancer activity, due to it closely relates to cell survival as well as apoptosis. Isolated from the glandular secretion of Australian tree frogs, the genus Litoria, host-defence caeri...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD015975 | Pride
Proteomics Hela cell Tmt labelling Tnfα signalling pathway Caerin peptide Apoptosis Confocal microscopy Western blot 
ProteomicsHost-defence peptide caerin 1.1 and 1.9 inhibited the proliferation of glioblastoma cells
Glioblastoma, the most aggressive form of brain cancer, remains a significant global contributor to mortality. Predictions of its increasing incidence in the coming decades underscore the need for more effective treatment strategies. Caerin 1.1 and 1.9, host defence peptides originally isolated from...
ORGANISM(S): Homo sapiens (Human) 
2024-06-08 | PXD044941 | Pride
Glioblastoma Caerin peptide Apoptosis Lc-ms/ms 
UnknownPreclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats.
Not available
S-EPMC9363195 | biostudies-literature
ProteomicsProteomic analysis of anti-MRSA activity of caerin 1.1/1.9 in a murine skin infection model
Caerin 1 is a family of host-defense peptides with antimicrobial property originally isolated from Australia tree frog. Caerin 1.1+1.9 has been shown to inhibit multiple antibiotic resistant bacteria infection both in vitro and in vivo. In current study, we compare the MICs of caerin 1.1/1.9 with c...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-11 | PXD044425 | Pride
Proteomics Anti-mrsa Caerin peptide 
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
UnknownComparative Proteomic Study of the Antiproliferative Activity of Frog Host-Defence Peptide Caerin 1.9 and Its Additive Effect with Caerin 1.1 on TC-1 Cells Transformed with HPV16 E6 and E7.
Not available
S-EPMC5971270 | biostudies-literature
UnknownCaerin 1.9-Titanium Plates Aid Implant Healing and Inhibit Bacterial Growth in New Zealand Rabbit Mandibles.
Not available
S-EPMC11551552 | biostudies-literature
UnknownThe membrane activity of the antimicrobial peptide caerin 1.1 is pH dependent.
Not available
S-EPMC10111263 | biostudies-literature
UnknownHost-Defense Peptides Caerin 1.1 and 1.9 Stimulate TNF-Alpha-Dependent Apoptotic Signals in Human Cervical Cancer HeLa Cells.
Not available
S-EPMC7412766 | biostudies-literature
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