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ProteomicsHost-defence peptides caerin 1.1 and 1.9 stimulate TNF-alpha-dependent apoptosis in human cervical cancer HeLa cells
TNFα pathway has been recognised as one of the most important signalling pathways characterising molecules with anti-cancer activity, due to it closely relates to cell survival as well as apoptosis. Isolated from the glandular secretion of Australian tree frogs, the genus Litoria, host-defence caeri...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD015975 | Pride
Proteomics Hela cell Tmt labelling Tnfα signalling pathway Caerin peptide Apoptosis Confocal microscopy Western blot 
ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
UnknownCaerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells.
Not available
S-EPMC12008296 | biostudies-literature
UnknownHost-Defense Peptides Caerin 1.1 and 1.9 Stimulate TNF-Alpha-Dependent Apoptotic Signals in Human Cervical Cancer HeLa Cells.
Not available
S-EPMC7412766 | biostudies-literature
UnknownComparative Proteomic Study of the Antiproliferative Activity of Frog Host-Defence Peptide Caerin 1.9 and Its Additive Effect with Caerin 1.1 on TC-1 Cells Transformed with HPV16 E6 and E7.
Not available
S-EPMC5971270 | biostudies-literature
ProteomicsProteomic analysis of anti-MRSA activity of caerin 1.1/1.9 in a murine skin infection model
Caerin 1 is a family of host-defense peptides with antimicrobial property originally isolated from Australia tree frog. Caerin 1.1+1.9 has been shown to inhibit multiple antibiotic resistant bacteria infection both in vitro and in vivo. In current study, we compare the MICs of caerin 1.1/1.9 with c...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-11 | PXD044425 | Pride
Proteomics Anti-mrsa Caerin peptide 
UnknownHost-defence caerin 1.1 and 1.9 peptides suppress glioblastoma U87 and U118 cell proliferation through the modulation of mitochondrial respiration and induce the downregulation of CHI3L1.
Not available
S-EPMC11161062 | biostudies-literature
UnknownCaerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophages.
Not available
S-EPMC11514859 | biostudies-literature
UnknownTopical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment.
Not available
S-EPMC8632150 | biostudies-literature
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