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TranscriptomicsTranscription profiling of Arabidopsis CAF-1 mutants
Comparison of Arabidopsis mutants lacking CAF-1 subunits
ORGANISM(S): Arabidopsis thaliana 
2022-11-22 | E-MEXP-694 | biostudies-arrayexpress
TranscriptomicsA novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix
The increased M-NM-1-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-cultu...
ORGANISM(S): Rattus norvegicus 
2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress
TranscriptomicsHuman carcinoma-associated fibroblasts (CAF): co-culture with cancer cells vs. CAF only
Gene expression profiling of CAF co-cultured with human oral squamous cell carcinoma (OSCC) cells compared with mono-cultured CAF. To identify key molecular regulators expressed by carcinoma-associated fibroblasts (CAF) that promote cancer cell invasion, microarrays were performed by comparing co-cu...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-18532 | biostudies-arrayexpress
TranscriptomicsCAF-1 safeguards somatic cell identity during factor-induced reprogramming
Cellular differentiation involves profound changes in the chromatic landscape, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNAi ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-72741 | biostudies-arrayexpress
TranscriptomicsHeterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast
Twenty-one genes (27 probe sets) were up-regulated in CAF, as compared with NF. Known functions of these genes relate to paracrine or intracellular signaling, transcriptional regulation, extracellular matrix and cell adhesion/migration. Ten genes (14 probe sets) were down-regulated in CAF, including...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20086 | biostudies-arrayexpress
GenomicsCAF-S3 subset in human breast and ovarian cancers
Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment. By combining 6 well-known stromal markers, we identify four CAF subsets (CAF-S1 to CAF-S4) in human breast and ovarian cancers.
EGAS00001003344 | EGA
TranscriptomicsaNOF vs. CAF
Compare the difference between pairwise aNOF and CAF samples for two patients patient #225: aNOF #225 vs CAF #225 patient #248: aNOF #248 vs CAF #248
ORGANISM(S): Homo sapiens 
2012-01-27 | E-GEOD-35249 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
TranscriptomicsGene expression in CAF-1 leaves
Chromatin assembly factor CAF-1 is conserved in all eukaryotes. In contrast to animals, plant CAF-1 is viable. Here we probe effects of loss of CAF-1 on the transcriptome of non-diving cells. Fully expanded rosette leaf 6 was collected from 10 35-d-old plants grown in short day photoperiods of wild ...
ORGANISM(S): Arabidopsis thaliana 
2015-11-02 | E-MTAB-2376 | biostudies-arrayexpress
TranscriptomicsGene expression in Arabidopsis CAF-1 mutant leaves
Chromatin assembly factor CAF-1 is conserved in all eukaryotes. In contrast to animals, plant CAF-1 is viable. Here we probe effects of loss of CAF-1 on the transcriptome of non-diving cells. Fully expanded rosette leaf 6 was collected from 10 35-d-old plants grown in short day photoperiods of wild ...
ORGANISM(S): Arabidopsis thaliana 
2018-08-31 | E-MTAB-6136 | biostudies-arrayexpress
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