Sort   by:  
 Page size 
TranscriptomicsCAF-1 safeguards somatic cell identity during factor-induced reprogramming
Cellular differentiation involves profound changes in the chromatic landscape, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNAi ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-72741 | biostudies-arrayexpress
GenomicsThe histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming (sequencing)
During development, specialized cell lineages are generated through the establishment of cell type-specific transcriptional patterns and epigenetic programs. However, the precise mechanisms and regulators that maintain these specialized cell states remain largely elusive. To identify molecules that ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-72744 | biostudies-arrayexpress
TranscriptomicsHistone chaperone CAF-1 is essential for retrotransposon silencing by mediating histone H4K20me3 deposition in mouse preimplantation embryos
Retrotransposons are widely spread in the mammalian genome and are usually silenced during development to avoid transposition-inducing mutations. But how they are repressed in embryos shortly before implantation remain to be identified, since the genome at this stage is globally hypomethylated. Here...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-69260 | biostudies-arrayexpress
TranscriptomicsHuman carcinoma-associated fibroblasts (CAF): co-culture with cancer cells vs. CAF only
Gene expression profiling of CAF co-cultured with human oral squamous cell carcinoma (OSCC) cells compared with mono-cultured CAF. To identify key molecular regulators expressed by carcinoma-associated fibroblasts (CAF) that promote cancer cell invasion, microarrays were performed by comparing co-cu...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-18532 | biostudies-arrayexpress
TranscriptomicsRNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
Totipotent cells that resemble 2-cell stage embryos (2C-like cells) can arise with a very low frequency in ES cell cultures. Here we show that totipotent-like cells can be induced in vitro through the down-regulation of the chromatin assembly activity of CAF-1. Endogenous retroviruses and 2-cell sta...
ORGANISM(S): Mus musculus 
2015-08-02 | E-MTAB-2684 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
UnknownThe Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones.
Not available
S-EPMC5045291 | biostudies-literature
UnknownThe CAF-1 complex couples Hippo pathway target gene expression and DNA replication.
Not available
S-EPMC6822585 | biostudies-literature
GenomicsFactors influencing in vivo deposition of histone variants H3.1 and H3.3
Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA histone chaperones. Impairing replicative H3.1 incorporation via CAF-1 enables an alternative H3.3 depos...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-31794 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of CAF1-CCR4-NOT1 deadenylase complex or AGO1 in D. melanogaster S2 cells
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. AGO1 is a key protein required for miRNA-mediated gene silencing. In animal cells, mRNA degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, fo...
ORGANISM(S): Drosophila melanogaster 
2008-12-03 | E-MEXP-1713 | biostudies-arrayexpress
Sort   by:  
 Page size