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MetabolomicsPrevotella copri mediated caffeine metabolism involves ferroptosis of osteoblasts in osteoarthritis

There is positive causality between coffee consumption and osteoarthritis (OA), however, whether gut microbiota is involved in it needs to be discussed. Here, we observed that, in caffeine consumers, fecal Prevotella copri (P. copri) abundance was positively correlated with subchondral bone mass,...

2025-03-21 | MTBLS11685 | MetaboLights
MetabolomicsCaffeine Enhances Antitumor T-cell Activity via COL12A1/IDO1/Kyn axis and Sensitivity to Anti-PD-1 Immunotherapy in Colorectal Cancer
Metabolomic sequencing on supernatants from caffeine-treated and untreated tumor cells to identify which metabolites are involved in activating CD8+ T cells
2025-05-06 | MTBLS11623 | MetaboLights
TranscriptomicsNext-Generation Sequencing Identifies Differentially Expressed Genes in Embryonic Hearts Following Caffeine Treatment
Purpose: This study aimed to identify differentially expressed genes including alternative splice variants in embryonic ventricles following in utero caffeine treatment. Methods: Pregnant CD-1 mice were injected with 20 mg/kg of caffeine or vehicle control daily from embryonic day (E) 6.5-9.5. On E...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-56902 | biostudies-arrayexpress
MetabolomicsFoHsf1 reprograms central metabolism via caffeine and vitamin D2 to modulate development and virulence of Fusarium oxysporum on Polygonatum kingianum
Root rot has severely affected the yield and quality of Polygonatum kingianum, and Fusarium oxysporum has been identified as the primary causal agent. To explore the virulence mechanisms of this pathogen, we performed a functional characterization of FoHsf1, a gene encoding a heat shock transcriptio...
2026-04-11 | MTBLS14221 | MetaboLights
TranscriptomicsTORC1 signaling pathway inhibition by rapamycin and caffeine affect lifespan, global gene expression and cell proliferation of fission yeast
Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here we analyzed the effects of rapamy...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-05 | E-MTAB-1489 | biostudies-arrayexpress
TranscriptomicsEffects of caffeine ingestion in Drosophila melanogaster male thorax and abdomen.
To screen for xenobiotic-metabolizing-enzyme genes (XME) induced by caffeine exposure, a microarray experiment (performed with a Drosophila pangenomic array (Agilent 4 X 44K) was carried out between control and individuals exposed to caffeine (18mM ). Among 23401 genes consistantly found in the thre...
ORGANISM(S): Drosophila melanogaster 
2014-07-04 | E-GEOD-59084 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer cell lines LS180 (MSI+) and SW480 (MSI-)
Inhibition of the nonsense mediated decay (NMD) mechanism in cells results in stabilization of transcripts carrying premature translation termination codons. A strategy referred to as gene indentification by NMD inhibition (GINI) has been proposed to identify genes carrying nonsense mutations (Noen...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5486 | biostudies-arrayexpress
ProteomicsCaffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells
Caffeine is a well-known purine alkaloid commonly found in coffee. Several lines of previous and recent evidence have shown that habitual coffee drinking is associated with lower risks for chronic kidney disease (CKD) and nephrolithiasis. However, cellular and molecular mechanisms underlying its ren...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-12-11 | PXD045313 | Pride
Ckd  coffee  energy  kidney  metabolism  nephrolithiasis  proteomics  renoprotection 
ProteomicsQuantitative proteomics reveals common and unique molecular mechanisms underlying beneficial effects of caffeine and trigonelline on human hepatocytes
Caffeine and trigonelline are the major bioactive compounds in coffee. Caffeine alone or combined with other coffee compounds shows hepatoprotective effects. However, molecular mechanisms underlying such hepatoprotective effects remain unclear. We therefore addressed molecular effects of caffeine an...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD037553 | Pride
Coffee  hepatoprotection  hepg2  protein synthesis  ribosome  translation 
ModelsShi1993_Caffeine_pressor_tolerance
described in: Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects Shi J, Benowitz NL, Denaro CP and Sheiner LB. ;Clin. Pharmacol. Ther. 1993 Jan;53(1):6-14. PMID:8422743; Abstract: We propose a parametric pharmacokinetic...
2024-09-02 | BIOMD0000000241 | BioModels
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