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ProteomicsTMT-based LC-MS/MS proteomics of cholesteatoma
Eight cases of middle ear cholesteatoma specimens and matched ear canal skin specimens
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD036926 |
ProteomicsNovel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing
Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptid...
ORGANISM(S): Homo Sapiens 
2025-04-02 | PXD062496 |
ProteomicsRoles of USP2/E2F4 axis in autophagic machinery essential for cancer progression
We investigated the potential proteins degraded by E2F4-induced autophagy via quantitative proteomics. To gain insight into protein partner essential for E2F4 stability, co-immunoprecipitation and mass spectrometry assays were performed.
ORGANISM(S): Homo Sapiens 
2021-11-19 | PXD029858 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
Proteomicsβ-thalassemia plasma EVs proteomics
Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the ...
ORGANISM(S): Homo Sapiens 
2022-06-15 | PXD034548 |
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