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TranscriptomicsMicroarray to study the effects of Snail overexpression in Glioblastoma cells.
Snail1 is a transcription factor known to promote the epithelial to mesenchymal transition process and stemness. We have previously described that in Glioblastoma BMP7 promotes glioblastoma initiating cells (GICs) to differentiate towards the astrocytic lineage and to lose their self-renewal capacit...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-6151 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis by AmpliSeq Ion Torrent to to understand the role of LKB1 and PARD3 in Glioblastoma biology
The aim of this work was to elucidate the role of LKB1/STK11 and PARD3 in glioblastoma multiforme cells. For this we silenced the expression of these proteins using specific siRNA in two different patient-derived glioblastoma stem cells, U3031MG and U3034MG, then we analysed how the knock-down of th...
ORGANISM(S): Homo sapiens 
2019-07-31 | E-MTAB-7724 | biostudies-arrayexpress
TranscriptomicsTransforming growth factor β (TGFβ) and BMP7 regulate glioblastoma stem cells differentiation status
Glioblastoma stem cells (GSCs) fate is controlled by environmental cues, among which cytokines play a crucial role. The transforming growth factor β (TGFβ) family signaling pathways controls GSCs. On one hand, TGFβ promotes cell proliferation in GBM, it induces the expression of platelet-derived gro...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9076 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis by AmpliSeq Ion Torrent to explore the effects of the long non-coding RNA TGFB2-AS1 on gene expression in human keratinocytes
TGFB2-AS1 is a long non-coding RNA which is induced by ΤGFβ signaling. In order to assess the importance of TGFB2-AS1 on the regulation of gene expression, we performed an AmpliSeq transcriptomic array in human keratinocytes (HaCaT), which stably over-express TGFB2-AS1 or control pcDNA3 empty vector...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7773 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis by AmpliSeq Ion Torrent to study the involvement of LINC00707 in the regulation of TGFβ target genes in HaCaT cells
The aim of this work was to elucidate the role of the lncRNA LINC00707 in HaCaT cells and study whether its downregulation mimics the effects of TGFβ treatment. To this end we used the HaCaT cells that were either transfected with a non-targeting shRNA (shC) and treated with TGFβ1 for 24 h (shC+TGFβ...
ORGANISM(S): Homo sapiens 
2023-06-02 | E-MTAB-12980 | biostudies-arrayexpress
TranscriptomicsIdentification of novel BMP target genes in glioblastoma
It has been previously described that in glioblastoma (GBM), BMPs deplete the tumorigenic potential of glioblastoma stem cells (GSCs), promoting their differentiation towards the astrocytic lineage. To gain more insight on how BMPs regulate differentiation in GSCs, we are interested in identifying n...
ORGANISM(S): Homo sapiens 
2021-05-01 | E-MTAB-9811 | biostudies-arrayexpress
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