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TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
TranscriptomicsThe long non-coding HOTAIR is modulated by cyclic stretch and WNT/beta-CATENIN in human aortic valve cells and is a novel repressor of calcification genes
Aortic valve calcification is a significant and serious clinical problem for which there are no effective medical treatments. Individuals born with bicuspid aortic valves, 1-2% of the population, are at the highest risk of developing aortic valve calcification. Aortic valve calcification involves in...
ORGANISM(S): Homo sapiens 
2014-05-02 | E-MTAB-2409 | biostudies-arrayexpress
ProteomicsComputational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
This study aimed to identify small molecules that inhibit vascular calcification with computational approach. To examine the mechanism of calcification inhibition, proteomics analysis was performed using aorta tissue samples to clarify therapeutic target.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029963 | Pride
Vascular calcification Proteomics Mice Wnt signaling Drug discovery Drug repurposing 
TranscriptomicsIntegrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification
Peripheral blood RNA-Seq from human coronary artery calcification cases and controls; Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an ...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-58150 | biostudies-arrayexpress
TranscriptomicsDifferentially enriched miRNAs in EVs derived from young and aged osteocytes of mice
Vascular calcification often occurs with osteoporosis, a contradictory association called “calcification paradox”. We find that extracellular vesicles (EVs) released from aged bone matrix (AB-EVs) during bone resorption favor adipogenesis rather than osteogenesis of BMSCs and augment calcification o...
ORGANISM(S): Mus musculus 
2022-02-15 | E-MTAB-11417 | biostudies-arrayexpress
TranscriptomicsGenetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice
Ectopic calcification in synovial tissues is devastating to diarthrodial joints. While some forms of synovial ectopic calcification have genetically simple basis, most cases manifest as complex traits with environmental and multigenic components. The location of causal loci or the physiological proc...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64793 | biostudies-arrayexpress
ProteomicsNuclear factor 90 isoform of vascular smooth muscle cells accelerates diabetic arteriosclerotic calcification by mediating FBXW7-AGER1-AGEs axis
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the prolonged accumulation of advanced glycation end products (AGEs) induced by hyperglycemia may be closely related to the pathogenesis of aortic calcification. However, the mechanisms underlying this assoc...
ORGANISM(S): Homo Sapiens 
PXD048707 |
TranscriptomicsDifferential miRNA expression in Cells and Matrix Vesicles in Vascular Smooth Muscle Cells from Rats with Kidney Disease
Vascular calcification is a complex process and has been associated with aging, diabetes, chronic kidney disease (CKD). Although there have been several studies studying the role of miRNAs (miRs) in bone osteogenesis, little is known about the role of miRs in vascular calcification and their role i...
ORGANISM(S): Rattus norvegicus 
2015-06-12 | E-GEOD-68913 | biostudies-arrayexpress
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
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