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ProteomicsProfile of growth factors in calf costochondral junction – the site of initial bone formation
Endochondral bone formation is orchestrated by growth factors produced by chondrocytes and deposited in cartilage matrix. Some of these factors were identified, but their complete list and relationship remains unknown. In this work the growth factors were isolated from calcified cartilage of costoch...
ORGANISM(S): Bos taurus (Bovine) 
2021-05-03 | PXD021781 | Pride
Growth factors Calcified cartilage Endochondral bone formation Osteoclasts 
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
TranscriptomicsHuman cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39795 | biostudies-arrayexpress
TranscriptomicsBovine cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Bos taurus 
2012-07-31 | E-GEOD-39796 | biostudies-arrayexpress
TranscriptomicsGene expression and alternative splicing data from human cartilage endplate-derived stem cells
Low back pain (LBP) is one of the most prevalent conditions which need medical advice and result in chronic disabilities. Degenerative disc disease (DDD) is a common reason for LBP. A lot of researchers think that CEP degeneration play critical roles in the initiation and development of DDD. In rece...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-63897 | biostudies-arrayexpress
TranscriptomicsRNA-seq of laser micro-dissected cartilage after surgical induction of osteoarthritis in increased ER stress mice
Osteoarthritis was induced in male wild-type and ColIITgcog (c/c) mice by destabilisation of the medial meniscus (DMM). c/c mice have increased ER stress in chondrocytes via the collagen II promoter driven expression of a misfolding protein, the cog form of thyroglobulin. RNA-sequencing of laser mic...
ORGANISM(S): Mus musculus 
2019-08-31 | E-MTAB-8266 | biostudies-arrayexpress
UnknownStudying the formation of the zone of calcified cartilage in bovine cartilage explants <i>ex vivo</i>.
Not available
S-EPMC12856866 | biostudies-literature
UnknownAnatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces.
Not available
S-EPMC7820185 | biostudies-literature
UnknownAutophagic LC3+ calcified extracellular vesicles initiate cartilage calcification in osteoarthritis.
Not available
S-EPMC9094669 | biostudies-literature
UnknownBioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair.
Not available
S-EPMC11228467 | biostudies-literature
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