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TranscriptomicsRNA sequencing data of osteoclasts subtypes in bone
Flow cytometrically sorted bone marrow osteoclasts from tibia of 2-weeks-old C57Bl/6 mice were used for generating this dataset. VAO and BAO represent RANK+ 2 nucleated and RANK+ 4 (and >4) nucleated osteoclasts from bone marrow respectively.
ORGANISM(S): Mus musculus 
2019-02-07 | E-MTAB-6857 | biostudies-arrayexpress
TranscriptomicsComparison expression data from wild-type and NFATc1-deficient osteoclasts
Genetic deletion of Nfatc1 in mice results in profound osteoclast-poor osteopetrosis, a high bone mass state caused by a lack of osteoclast activity. We hypothesized that the family of NFATc1 regulated transcripts in the osteoclast would be enriched for genes associated with osteoclast function. We...
ORGANISM(S): Mus musculus 
2012-08-18 | E-GEOD-37219 | biostudies-arrayexpress
TranscriptomicsMurine Osteoclasts: Stat5 flox vs. Stat5 cKO
Transcriptional profiling of mouse osteoclasts comparing control osteoclasts from Stat5 flox mice with osteoclasts from Stat5 cKO mice. Two-condition experiment, Stat5 flox cells vs. Stat5 cKO cells
ORGANISM(S): Mus musculus 
2013-12-09 | E-GEOD-51283 | biostudies-arrayexpress
ProteomicsSQSTM1-interacting proteins in human osteoclasts
SQSTM1-interacting proteins in human osteoclasts
ORGANISM(S): Homo sapiens (Human) 
2012-03-04 | PRD000309 | Pride
TranscriptomicsExpression data from cultured macrophages and osteoclasts
Osteoclastogenesis is induced by the stimulation of RANKL. In the early stage of osteoclast differentiation, the osteoclast progenitor cells are primed by M-CSF, following a tightly controlled genetic program where specific sets of genes are up-regulated by RANKL. Some of them, for instance, control...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-20850 | biostudies-arrayexpress
TranscriptomicsExpression data from osteoclasts before and after co-culture with multiple myeloma plasma cells
To understand how interactions of myeloma cells with osteoclasts and mesenchymal stem cells in the bone marrow affect the clinical course of myeloma, we used microarrays to study changes in gene expression in freshly isolated myeloma plasma cells following co-cultures with osteoclasts (8 experiments...
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-31156 | biostudies-arrayexpress
TranscriptomicsCalcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiq...
ORGANISM(S): Mus musculus 
2014-10-19 | E-GEOD-60761 | biostudies-arrayexpress
GenomicsFibroblasts in cholesteatoma activate osteoclasts.
Fibroblasts in cholesteatoma activate osteoclasts.
PRJNA477370 | ENA
GenomicsSex differential gene expression in macrophages and osteoclasts
Sex differential gene expression in macrophages and osteoclasts
PRJNA896199 | ENA
GenomicsChromatin Accessibility Profiling of Osteoclasts Precursor Cells
Chromatin Accessibility Profiling of Osteoclasts Precursor Cells
PRJNA839624 | ENA
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